GPI-PLD Antibody (E-5): sc-365873

GPI-PLD Antibody (E-5) is a mouse monoclonal IgG1 antibody that detects phosphatidylinositol-glycan-specific phospholipase D (GPI-PLD) in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). GPI-PLD plays a crucial role in lipid metabolism by hydrolyzing the inositol phosphate linkage in proteins anchored by phosphatidylinositol-glycans, which is essential for the release of glycosylphosphatidylinositol (GPI)-anchored proteins from the cell surface. This process regulates various cellular functions, including cell signaling and adhesion, and is implicated in inflammatory responses. GPI-PLD is predominantly associated with high-density lipoproteins and is found in serum, liver, cerebrospinal fluid, and milk, highlighting GPI-PLD′s importance in both systemic and localized physiological processes. Research indicates that serum GPI-PLD activity is markedly reduced in conditions such as systemic inflammatory response syndrome, suggesting that GPI-PLD downregulation may contribute to the modulation of proinflammatory responses, making GPI-PLD a potential target for therapeutic intervention. Anti-GPI-PLD antibody (E-5) is an invaluable tool for researchers investigating GPI-PLD′s role in health and disease.

The preferred GPI-PLD antibody is GPI-PLD Antibody (D-10): sc-365096.