GP73 Antibody (F-12): sc-393372
- GP73 Antibody (F-12) is a mouse monoclonal IgG2a κ, cited in 1 publications, provided at 200 µg/ml
- specific for an epitope mapping between amino acids 330-364 near the C-terminus of GP73 of human origin
- recommended for detection of GP73 of human origin by WB, IP, IF and ELISA
- See GP73 (F-2): sc-365817 for GP73 antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- m-IgG Fc BP-HRP and m-IgG2a BP-HRP are the preferred secondary detection reagents for GP73 Antibody (F-12) for WB applications. These reagents are now offered in bundles with GP73 Antibody (F-12) (see ordering information below).
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GP73 Antibody (F-12) is a mouse monoclonal IgG2a antibody that detects GP73 in human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). GP73, also known as Golgi phosphoprotein 2, GOLPH 2, or Golgi membrane protein, is a type II transmembrane protein predominantly located in the Golgi apparatus, where GP73 plays a crucial role in the post-translational modification of proteins synthesized in the rough endoplasmic reticulum. This function ensures proteins are properly modified and sorted for specific cellular functions, which is essential for maintaining cellular homeostasis and facilitating intercellular communication. GP73 levels are significantly elevated in individuals diagnosed with acute and chronic liver diseases, making GP73 a potential biomarker for liver dysfunction. Anti-GP73 antibody (F-12) provides a reliable tool for researchers investigating GP73′s role in various biological processes and implications in liver pathology.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
GP73 Antibody (F-12) References:
- GP73 expression and its significance in the diagnosis of hepatocellular carcinoma: a review. | Ba, MC., et al. 2012. Int J Clin Exp Pathol. 5: 874-81. PMID: 23119104
- GP73 regulates Hepatic Steatosis by enhancing SCAP-SREBPs interaction. | Yang, X., et al. 2017. Sci Rep. 7: 14932. PMID: 29097707
- The Clinical Significance of GP73 in Immunologically Mediated Chronic Liver Diseases: Experimental Data and Literature Review. | Yao, M., et al. 2018. Clin Rev Allergy Immunol. 54: 282-294. PMID: 29256057
- Research progress on GP73 in malignant tumors. | Liang, R., et al. 2018. Onco Targets Ther. 11: 7417-7421. PMID: 30425529
- Serum GP73 predicts posthepatectomy outcomes in patients with hepatocellular carcinoma. | Ke, MY., et al. 2019. J Transl Med. 17: 140. PMID: 31046807
- GP73 facilitates hepatitis B virus replication by repressing the NF-κB signaling pathway. | Liu, L., et al. 2020. J Med Virol. 92: 3327-3335. PMID: 32077512
- GP73 is a TBC-domain Rab GTPase-activating protein contributing to the pathogenesis of non-alcoholic fatty liver disease without obesity. | Peng, Y., et al. 2021. Nat Commun. 12: 7004. PMID: 34853313
- GP73 links SARS-CoV-2 infection with dysglycaemia. | Coate, KC. 2022. Nat Metab. 4: 9-10. PMID: 34992300
- GP73 blockade alleviates abnormal glucose homeostasis in diabetic mice. | Yang, X., et al. 2023. J Mol Endocrinol. 70: PMID: 36394986
- GP73 enhances the ox-LDL-induced inflammatory response in THP-1 derived macrophages via affecting NLRP3 inflammasome signaling. | Lin, YF., et al. 2023. Int J Cardiol. 387: 131109. PMID: 37271284
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
GP73 Antibody (F-12) | sc-393372 | 200 µg/ml | $322.00 | |||
GP73 Antibody (F-12): m-IgG Fc BP-HRP Bundle | sc-540900 | 200 µg Ab; 10 µg BP | $361.00 | |||
GP73 Antibody (F-12): m-IgG2a BP-HRP Bundle | sc-546971 | 200 µg Ab; 10 µg BP | $361.00 | |||
GP73 (F-12) Neutralizing Peptide | sc-393372 P | 100 µg/0.5 ml | $69.00 |