GP-39 Antibody (D-11): sc-393494

GP-39 Antibody (D-11) is a mouse monoclonal IgM antibody that detects GP-39 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). Anti-GP-39 antibody (D-11) is available as the non-conjugated form. Human cartilage glycoprotein 39 (GP-39), also known as YKL-40, is a glycoprotein secreted by articular chondrocytes, synoviocytes, and macrophages, playing a crucial role in the inflammatory response. Elevated levels of GP-39 in serum and synovial fluid are associated with inflammatory diseases, particularly correlating with the degree of joint destruction in rheumatoid arthritis, making GP-39 a significant biomarker for disease progression. GP-39 is primarily expressed in articular chondrocytes and synovial cells, with additional expression in the liver, while remaining undetectable in muscle tissues, lung, pancreas, mononuclear cells, and fibroblasts. GP-39′s structure, characterized by glycosylation and ability to form homodimers, is essential for modulating inflammation and tissue remodeling. GP-39′s role as a candidate autoantigen in rheumatoid arthritis highlights GP-39′s importance in the immune response, as GP-39 aids cells in adapting to environmental changes, thus contributing to the pathophysiology of joint diseases.

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GP-39 Antibody (D-11) References:

1. Strong induction of members of the chitinase family of proteins in atherosclerosis: chitotriosidase and human cartilage gp-39 expressed in lesion macrophages.  |  Boot, RG., et al. 1999. Arterioscler Thromb Vasc Biol. 19: 687-94. PMID: 10073974
2. The human T cell antigen gp39, a member of the TNF gene family, is a ligand for the CD40 receptor: expression of a soluble form of gp39 with B cell co-stimulatory activity.  |  Hollenbaugh, D., et al. 1992. EMBO J. 11: 4313-21. PMID: 1385114
3. Detection of major histocompatibility complex/human cartilage gp-39 complexes in rheumatoid arthritis synovitis as a specific and independent histologic marker.  |  Baeten, D., et al. 2004. Arthritis Rheum. 50: 444-51. PMID: 14872486
4. The phylogenetically conserved molluscan chitinase-like protein 1 (Cg-Clp1), homologue of human HC-gp39, stimulates proliferation and regulates synthesis of extracellular matrix components of mammalian chondrocytes.  |  Badariotti, F., et al. 2006. J Biol Chem. 281: 29583-96. PMID: 16882657
5. Lack of evidence for association of two functional SNPs of CHI3L1 gene (HC-gp39) with rheumatoid arthritis.  |  Srivastava, SK., et al. 2011. Rheumatol Int. 31: 1003-7. PMID: 20300754
6. Characterization of gp39, a B-lymphocyte associated differentiation antigen which is also present on granulocytes and macrophages.  |  Lauzon, GJ., et al. 1988. Mol Immunol. 25: 829-41. PMID: 3264883
7. Interaction between CD40 and its ligand gp39 in the development of murine lupus nephritis.  |  Mohan, C., et al. 1995. J Immunol. 154: 1470-80. PMID: 7529804
8. Studies on the interdependence of gp39 and B7 expression and function during antigen-specific immune responses.  |  Roy, M., et al. 1995. Eur J Immunol. 25: 596-603. PMID: 7533092
9. Therapeutic potential for blockade of the CD40 ligand, gp39.  |  Buhlmann, JE. and Noelle, RJ. 1996. J Clin Immunol. 16: 83-9. PMID: 8690776
10. Molecular characterization of the gene for human cartilage gp-39 (CHI3L1), a member of the chitinase protein family and marker for late stages of macrophage differentiation.  |  Rehli, M., et al. 1997. Genomics. 43: 221-5. PMID: 9244440

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-GP-39 Antibody (D-11) has 1 citations in a variety of scientific publications.

Primary antibodies like Anti-GP-39 Antibody (D-11) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

GP-39 Antibody (D-11) Specifications

Alternate Product Name: GP-39

Product Clone Name: D-11

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgM kappa light chain

Amino Acids: 28-42

Epitope Target: GP-39

Epitope Species: human

Product Reactivity/Detection: GP-39

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: bovine and porcine

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 200 µg IgM kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 1 citations in various scientific publications

Available Conjugates/Forms for GP-39 Antibody (D-11): P: Blocking Peptide

The preferred GP-39 antibody is GP-39 Antibody (E-11): sc-376910.