GnRH I Antibody (7B101D10): sc-33675

GnRH I Antibody (7B101D10) is a mouse monoclonal IgG1 antibody that detects gonadotropin-releasing hormone (GnRH) in mouse, rat, and human samples through immunofluorescence (IF) applications. GnRH plays a crucial role in human reproduction by orchestrating the hypothalamic-pituitary-gonadal axis, a complex control circuit established early in fetal development. GnRH I (7B101D10) antibody recognizes this decapeptide synthesized by hypothalamic neurons and released in a pulsatile manner, influencing luteinizing hormone and follicle-stimulating hormone secretion from gonadotropic cells in the anterior pituitary. GnRH expression occurs not only in the hypothalamus but also in the acrosomal region of human sperm and various cancer cells, indicating potential involvement in reproductive processes and tumor biology. A second form, GnRH II, predominantly found in the midbrain and expressed in tissues such as kidney, bone marrow, and prostate, suggests diverse functions beyond reproduction. GnRH binding to its specific G protein-coupled receptor in the pituitary is essential for gonadotropin synthesis and secretion, highlighting GnRH′s importance in reproductive health and disease. Anti-GnRH antibody (7B101D10) serves as an invaluable tool for researchers investigating reproductive biology and related disorders.

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GnRH I Antibody (7B101D10) References:

1. GnRH and GnRH receptor genes in the human genome.  |  Neill, JD. 2002. Endocrinology. 143: 737-43. PMID: 11861490
2. The neuropeptides GnRH-II and GnRH-I are produced by human T cells and trigger laminin receptor gene expression, adhesion, chemotaxis and homing to specific organs.  |  Chen, A., et al. 2002. Nat Med. 8: 1421-6. PMID: 12447356
3. Relative effect of gonadotropin-releasing hormone (GnRH)-I and GnRH-II on gonadotropin release.  |  Densmore, VS. and Urbanski, HF. 2003. J Clin Endocrinol Metab. 88: 2126-34. PMID: 12727965
4. Cellular localization of gonadotropin-releasing hormone (GnRH) I and GnRH II in first-trimester human placenta and decidua.  |  Chou, CS., et al. 2004. J Clin Endocrinol Metab. 89: 1459-66. PMID: 15001648
5. GnRH tandem peptides for inducing an immunogenic response to GnRH-I without cross-reactivity to other GnRH isoforms.  |  Turkstra, JA., et al. 2005. Vaccine. 23: 4915-20. PMID: 16006018
6. Analogs of GnRH-I and GnRH-II inhibit epidermal growth factor-induced signal transduction and resensitize resistant human breast cancer cells to 4OH-tamoxifen.  |  Günthert, AR., et al. 2005. Eur J Endocrinol. 153: 613-25. PMID: 16189183
7. Immunolocalization of gonadotropin-releasing hormone (GnRH)-I, GnRH-II, and type I GnRH receptor during follicular development in the human ovary.  |  Choi, JH., et al. 2006. J Clin Endocrinol Metab. 91: 4562-70. PMID: 16954155
8. GnRH-I and GnRH-II-induced calcium signaling and hormone secretion in neonatal rat gonadotrophs.  |  Balík, A., et al. 2009. Physiol Res. 58: 709-716. PMID: 19093727
9. Gonadotropin-releasing hormone (GnRH)-I and GnRH-II induce cell growth inhibition in human endometrial cancer cells: involvement of integrin beta3 and focal adhesion kinase.  |  Park, DW., et al. 2009. Reprod Biol Endocrinol. 7: 81. PMID: 19656390
10. Preparation of a radiolabeled GnRH-I analogue derivative with 111 In as a new anti-proliferative agent.  |  Zoghi, M., et al. 2018. J Labelled Comp Radiopharm. 61: 903-911. PMID: 30109712

The preferred GnRH I antibody is GnRH I Antibody (HU11B): sc-32292.