GnRH I Antibody (7B101D10): sc-33675
- GnRH I Antibody (7B101D10) is a mouse monoclonal IgG1, cited in 3 publications, provided at 200 µg/ml
- raised against amino acids 25 -33 of GnRH I of rat origin
- recommended for detection of GnRH I of mouse, rat and human origin by IF; non cross-reactive with GnRH II and GnRH III
- See GnRH I (A-4): sc-271918 for GnRH I antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for GnRH I Antibody (7B101D10). This work is in progress.
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GnRH I Antibody (7B101D10) is a mouse monoclonal IgG1 antibody that detects gonadotropin-releasing hormone (GnRH) in mouse, rat, and human samples through immunofluorescence (IF) applications. GnRH plays a crucial role in human reproduction by orchestrating the hypothalamic-pituitary-gonadal axis, a complex control circuit established early in fetal development. GnRH I (7B101D10) antibody recognizes this decapeptide synthesized by hypothalamic neurons and released in a pulsatile manner, influencing luteinizing hormone and follicle-stimulating hormone secretion from gonadotropic cells in the anterior pituitary. GnRH expression occurs not only in the hypothalamus but also in the acrosomal region of human sperm and various cancer cells, indicating potential involvement in reproductive processes and tumor biology. A second form, GnRH II, predominantly found in the midbrain and expressed in tissues such as kidney, bone marrow, and prostate, suggests diverse functions beyond reproduction. GnRH binding to its specific G protein-coupled receptor in the pituitary is essential for gonadotropin synthesis and secretion, highlighting GnRH′s importance in reproductive health and disease. Anti-GnRH antibody (7B101D10) serves as an invaluable tool for researchers investigating reproductive biology and related disorders.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
GnRH I Antibody (7B101D10) | sc-33675 | 200 µg/ml | $322.00 |