GMPS Antibody (D-5): sc-374225
- GMPS Antibody (D-5) is a mouse monoclonal IgG1 κ provided at 200 µg/ml
- raised against a peptide mapping at the C-terminus of GMPS of human origin
- recommended for detection of GMPS of mouse, rat and human origin by WB, IP, IF and ELISA
- m-IgG Fc BP-HRP and m-IgG1 BP-HRP are the preferred secondary detection reagents for GMPS Antibody (D-5) for WB applications. These reagents are now offered in bundles with GMPS Antibody (D-5) (see ordering information below).
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GMPS Antibody (D-5) is a mouse monoclonal IgG1 antibody that detects GMPS in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). GMPS, or guanine monophosphate synthetase, is a vital 693 amino acid cytoplasmic protein that plays a crucial role in purine biosynthesis, specifically catalyzing the final step in the synthesis of GMP from XMP in an ATP-dependent manner. This enzyme exists as a homodimer and features a GMP-binding domain along with a glutamine amidotransferase type-1 domain, which are essential for its catalytic function. Proper functioning of GMPS is critical for maintaining cellular energy levels and supporting various metabolic processes, as purines are fundamental for energy metabolism, cell signaling, and the synthesis of nucleic acids. Notably, chromosomal translocations involving GMPS have been linked to acute myeloid leukemias, highlighting GMPS′s potential role in cancer development and making anti-GMPS antibody (D-5) a significant tool for research in oncology.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
GMPS Antibody (D-5) | sc-374225 | 200 µg/ml | $322.00 | |||
GMPS Antibody (D-5): m-IgG Fc BP-HRP Bundle | sc-540426 | 200 µg Ab; 10 µg BP | $361.00 | |||
GMPS Antibody (D-5): m-IgG1 BP-HRP Bundle | sc-542113 | 200 µg Ab; 20 µg BP | $361.00 |