GMF-γ Antibody (778J2F): sc-517637

GMF-γ Antibody (778J2F) is a mouse monoclonal IgG1 antibody that detects GMF-gamma protein of human origin by western blotting (WB). Anti-GMF-gamma antibody (778J2F) is available as a non-conjugated format. GMF-gamma, or glia maturation factor gamma, is a 142 amino acid protein that plays a crucial role in cellular processes by acting as a candidate regulatory growth factor. GMF-gamma is predominantly expressed in vital organs such as the lung, heart, and placenta, where GMF-gamma mediates both paracrine and autocrine cell-cell interactions, thereby influencing tissue development and repair. Notably, GMF-gamma is involved in the regulation of actin dynamics, which is essential for various cellular functions, including motility and morphology. GMF-gamma undergoes phosphorylation at its N-terminal serine, a modification that is significantly enhanced by the coexpression of dominant active Rac 1 and Cdc42, two important regulators of the cytoskeleton. This post-translational modification is critical as phosphorylation can alter GMF-gamma′s activity and interactions, particularly in the context of cardiac ischemia/reperfusion, where GMF-gamma expression is markedly increased during inflammation and angiogenesis. By understanding the functional implications of GMF-gamma and its regulatory role in actin-based cellular functions, researchers can explore novel therapeutic strategies for cardiovascular diseases and other conditions where cell signaling and growth factor regulation are disrupted.

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GMF-γ Antibody (778J2F) References:

1. Cloning of a rat glia maturation factor-gamma (rGMFG) cDNA and expression of its mRNA and protein in rat organs.  |  Tsuiki, H., et al. 2000. J Biochem. 127: 517-23. PMID: 10731725
2. [Review of the research of glia maturation factor and cloning of human and rat glia maturation factor-gamma (GMFG) cDNA].  |  Asai, K. 2001. Nihon Shinkei Seishin Yakurigaku Zasshi. 21: 15-20. PMID: 11400321
3. Expression of glia maturation factor during retinal development in the rat.  |  Nishiwaki, A., et al. 2001. Brain Res Mol Brain Res. 95: 103-9. PMID: 11687281
4. Sensitive immunoassays for human and rat GMFB and GMFG, tissue distribution and age-related changes.  |  Inagaki, M., et al. 2004. Biochim Biophys Acta. 1670: 208-16. PMID: 14980447
5. Expression of glia maturation factor beta after cryogenic brain injury.  |  Hotta, N., et al. 2005. Brain Res Mol Brain Res. 133: 71-7. PMID: 15661366
6. Glia maturation factor-gamma is preferentially expressed in microvascular endothelial and inflammatory cells and modulates actin cytoskeleton reorganization.  |  Ikeda, K., et al. 2006. Circ Res. 99: 424-33. PMID: 16873721
7. Glia maturation factor gamma (GMFG): a cytokine-responsive protein during hematopoietic lineage development and its functional genomics analysis.  |  Shi, Y., et al. 2006. Genomics Proteomics Bioinformatics. 4: 145-55. PMID: 17127212
8. Regulation of granulosa and theca cell transcriptomes during ovarian antral follicle development.  |  Skinner, MK., et al. 2008. Mol Reprod Dev. 75: 1457-72. PMID: 18288646
9. Glia maturation factor modulates beta-amyloid-induced glial activation, inflammatory cytokine/chemokine production and neuronal damage.  |  Zaheer, A., et al. 2008. Brain Res. 1208: 192-203. PMID: 18395194