GMF-β Antibody (SP-61): sc-134347

GMF-β Antibody (SP-61) is a mouse monoclonal IgG1 kappa light chain antibody that detects GMF-beta protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). GMF-beta (SP-61) antibody is available as the non-conjugated form. Glia maturation factor beta (GMF-β) is a critical protein that plays a significant role in the nervous system, particularly in brain cell differentiation and neural regeneration. GMF-beta protein is phosphorylated following phorbol ester stimulation, which enhances activity in promoting neuroprotection and inhibiting tumor cell proliferation. GMF-beta protein has been shown to increase the production of brain-derived neurotrophic factor (BDNF) in astrocytes, a process that is further stimulated by exercise, highlighting GMF-beta′s importance in exercise-induced neuroprotection. GMF-beta protein is produced by thymoma tumor cells, which is essential for maintaining T-cell development in that context. GMF-beta′s ability to interact with various signaling pathways underscores potential as a therapeutic target in neurodegenerative diseases and cancer, making GMF-beta (SP-61) antibody a valuable tool for researchers studying these critical biological processes.

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GMF-β Antibody (SP-61) References:

1. Presence of angiotensin peptides in human urine.  |  Hermann, K., et al. 1992. Clin Chem. 38: 1768-72. PMID: 1526012
2. Impaired motor performance and learning in glia maturation factor-knockout mice.  |  Lim, R., et al. 2004. Brain Res. 1024: 225-32. PMID: 15451385
3. Echocardiography for evaluating anatomic repair of transposition of the great arteries.  |  Rees, AH., et al. 1992. South Med J. 85: 370-4. PMID: 1566136
4. Glia maturation factor-beta is produced by thymoma and may promote intratumoral T-cell differentiation.  |  Yamazaki, H., et al. 2005. Histopathology. 47: 292-302. PMID: 16115230
5. GMF-knockout mice are unable to induce brain-derived neurotrophic factor after exercise.  |  Zaheer, A., et al. 2006. Neurochem Res. 31: 579-84. PMID: 16758368
6. Molecular cloning and expression of biologically active human glia maturation factor-beta.  |  Kaplan, R., et al. 1991. J Neurochem. 57: 483-90. PMID: 1712830
7. Phorbol ester stimulates rapid intracellular phosphorylation of glia maturation factor.  |  Lim, R. and Zaheer, A. 1995. Biochem Biophys Res Commun. 211: 928-34. PMID: 7598724

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-GMF-β Antibody (SP-61) has 5 citations in a variety of scientific publications.

Primary antibodies like Anti-GMF-β Antibody (SP-61) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

GMF-β Antibody (SP-61) Specifications

Alternate Product Name: GMF-β

Product Clone Name: SP-61

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 1-155

Epitope Target: GMF-β

Epitope Species: human

Product Reactivity/Detection: GMF-β

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 100 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 5 citations in various scientific publications

Available Conjugates/Forms for GMF-β Antibody (SP-61): N/A