GM-CSFRα Antibody (8G6): sc-73545

GM-CSFRα Antibody (8G6) is a mouse monoclonal IgG1 antibody that detects GM-CSFRα in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and flow cytometry (FCM). GM-CSFRα, or Granulocyte-Macrophage Colony-Stimulating Factor Receptor Alpha, plays a crucial role in hematopoiesis and immune response by mediating the effects of granulocyte-macrophage colony-stimulating factor (GM-CSF), which is essential for the proliferation, differentiation, and survival of myeloid progenitor cells. GM-CSFRα is primarily located on the surface of hematopoietic cells, including monocytes, macrophages, and neutrophils, where GM-CSFRα facilitates the binding of GM-CSF, leading to the activation of downstream signaling pathways that promote cell survival and proliferation. Understanding the localization and function of GM-CSFRα is vital, as dysregulation of GM-CSFRα can contribute to various hematological disorders and impact immune responses, making GM-CSFRα a significant target for therapeutic interventions. Anti-GM-CSFRα antibody (8G6) is an invaluable tool for researchers studying the role of GM-CSF in immune regulation and its implications in disease.

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GM-CSFRα Antibody (8G6) References:

1. The Ig-like domain of human GM-CSF receptor alpha plays a critical role in cytokine binding and receptor activation.  |  Mirza, S., et al. 2010. Biochem J. 426: 307-17. PMID: 20078425
2. Protein engineering and preclinical development of a GM-CSF receptor antibody for the treatment of rheumatoid arthritis.  |  Minter, RR., et al. 2013. Br J Pharmacol. 168: 200-11. PMID: 22913645
3. Granulocyte-macrophage colony-stimulating factor (GM-CSF) is released by female mouse bladder urothelial cells and expressed by the urothelium as an early response to lipopolysaccharides (LPS).  |  Li, Y., et al. 2017. Neurourol Urodyn. 36: 1020-1025. PMID: 27337494
4. Neutrophil GM-CSF receptor dynamics in acute lung injury.  |  De Alessandris, S., et al. 2019. J Leukoc Biol. 105: 1183-1194. PMID: 30942918
5. Expression of granulocyte macrophage-colony stimulating factor and its receptor in the synovium of osteoarthritis patients is negatively correlated with pain.  |  van Helvoort, EM., et al. 2020. Rheumatology (Oxford). 59: 3452-3457. PMID: 32365364
6. Dense GM-CSFRα-expressing immune infiltration is allied with longer survival of intrahepatic cholangiocarcinoma patients.  |  Saranaruk, P., et al. 2023. PeerJ. 11: e14883. PMID: 36883059
7. GM-CSF Promotes the Survival of Peripheral-Derived Myeloid Cells in the Central Nervous System for Pain-Induced Relapse of Neuroinflammation.  |  Matsuyama, S., et al. 2023. J Immunol. 211: 34-42. PMID: 37212607
8. Renal denervation achieves its antiarrhythmic effect through attenuating macrophage activation and neuroinflammation in stellate ganglia in chronic heart failure.  |  Hu, W., et al. 2024. Cardiovasc Res.. PMID: 39321201
9. The cytoplasmic domain of granulocyte-macrophage colony-stimulating factor (GM-CSF) receptor alpha subunit is essential for both GM-CSF-mediated growth and differentiation.  |  Matsuguchi, T., et al. 1997. J Biol Chem. 272: 17450-9. PMID: 9211889
10. Cytoplasmic domains of the human granulocyte-macrophage colony-stimulating factor (GM-CSF) receptor beta chain (hbetac) responsible for human GM-CSF-induced myeloid cell differentiation.  |  Matsuguchi, T., et al. 1998. J Biol Chem. 273: 19411-8. PMID: 9677359

The preferred GM-CSFRα antibody is GM-CSFRα Antibody (S-50): sc-456.