Glyoxalase II Antibody (A-11): sc-365233
- Glyoxalase II Antibody (A-11) is a mouse monoclonal IgG3 κ, cited in 2 publications, provided at 200 µg/ml
- specific for an epitope mapping between amino acids 222-250 near the C-terminus of Glyoxalase II of human origin
- recommended for detection of Glyoxalase II of mouse, rat and human origin by WB, IP, IF and ELISA; also reactive with additional species, including and equine and canine
- m-IgG3 BP-HRP is the preferred secondary detection reagent for Glyoxalase II Antibody (A-11) for WB applications. This reagent is now offered in a bundle with Glyoxalase II Antibody (A-11) (see ordering information below).
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Glyoxalase II Antibody (A-11) is a mouse monoclonal IgG3 antibody that detects Glyoxalase II in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Glyoxalase II is a crucial enzyme in the glyoxalase pathway, which plays a significant role in detoxifying glucose degradation products, thereby protecting cells from oxidative stress and potential damage. This enzyme functions as a thiolesterase, catalyzing the hydrolysis of S-D-lactoyl-glutathione to produce reduced glutathione and D-lactic acid, which are vital for maintaining cellular redox balance. Glyoxalase II is composed of 260 amino acids and uniquely exists as a monomer, binding two zinc ions per subunit, which is essential for enzymatic activity. The localization of Glyoxalase II in both the mitochondria and cytosol of mammalian cells underscores its importance in cellular metabolism and detoxification processes. Notably, elevated levels of Glyoxalase II activity have been observed in breast cancer tissues compared to matched unaffected tissues, indicating potential as a therapeutic target and suggesting that glyoxalase inhibitor drugs may offer promising avenues for cancer treatment. Anti-Glyoxalase II antibody (A-11) is an invaluable tool for researchers investigating this enzyme in various biological contexts, particularly in cancer research.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Glyoxalase II Antibody (A-11) | sc-365233 | 200 µg/ml | $322.00 | |||
Glyoxalase II Antibody (A-11): m-IgG3 BP-HRP Bundle | sc-550421 | 200 µg Ab; 40 µg BP | $361.00 | |||
Glyoxalase II Antibody (A-11): m-IgGκ BP-HRP Bundle | sc-551861 | 200 µg Ab; 40 µg BP | $361.00 | |||
Glyoxalase II (A-11) Neutralizing Peptide | sc-365233 P | 100 µg/0.5 ml | $69.00 |