Glycogenin-1 Antibody (4H8): sc-100537

Glycogenin-1 Antibody (4H8) is a mouse monoclonal IgG2a antibody that detects Glycogenin-1 in mouse, rat, and human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). Glycogenin-1 plays a crucial role in glycogen synthesis, serving as a primer for the addition of glucose monomers in mammalian skeletal muscle. Glycogenin-1 is located in the cytoplasm, where Glycogenin-1 initiates glycogen formation by autoglucosylation, a process vital for energy storage and regulation in cells. Glycogenin-1′s unique ability to self-glucosylate allows Glycogenin-1 to catalyze the addition of glucose units from UDP-glucose, creating a short glucose chain essential for the subsequent action of glycogen synthase, which elongates the glycogen molecule. This initial step establishes the foundation for glycogen storage, necessary for maintaining energy homeostasis in the body. Glycogenin-1 remains covalently attached to the reducing end of the glycogen molecule, ensuring that the structure is stable and functional for energy mobilization when needed. Anti-Glycogenin-1 antibody (4H8) is an invaluable tool for researchers studying glycogen metabolism and related disorders, providing insights into the mechanisms of energy storage and utilization in various physiological contexts.

The preferred Glycogenin-1 antibody is Glycogenin-1 Antibody (E-11): sc-271109.