Glucose Transporter Glut2 Antibody (C-10): sc-518022

Glut2 Antibody (C-10) is a mouse monoclonal IgG1 kappa light chain antibody that detects Glut2 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). anti-Glut2 antibody (C-10) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. Glut2 plays a crucial role in glucose homeostasis, functioning primarily as a low-affinity glucose transporter that facilitates glucose transport across cell membranes in response to varying glucose concentrations. Glut2 expression is particularly significant in pancreatic beta cells, where Glut2 is involved in glucose sensing and insulin secretion, as well as in hepatocytes and the basolateral membranes of intestinal epithelial cells. Glut2′s ability to transport glucose efficiently under high glucose conditions is vital for maintaining energy balance and metabolic regulation. Glut2′s unique low-affinity characteristic allows Glut2 to act as a glucose sensor, providing critical feedback to the pancreas regarding blood glucose levels, which is essential for proper insulin secretion mechanisms. Glut2 serves as a key player in glucose metabolism regulation and a potential target for therapeutic interventions in metabolic disorders.

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Glucose Transporter Glut2 Antibody (C-10) References:

1. GLUT2, glucose sensing and glucose homeostasis.  |  Thorens, B. 2015. Diabetologia. 58: 221-32. PMID: 25421524
2. PAR2 promotes impaired glucose uptake and insulin resistance in NAFLD through GLUT2 and Akt interference.  |  Shearer, AM., et al. 2022. Hepatology. 76: 1778-1793. PMID: 35603482
3. Kidney Proximal Tubule GLUT2-More than Meets the Eye.  |  Ahmad, M., et al. 2022. Cells. 12: PMID: 36611887
4. GLUT2, glucose and oxygen sensing in CD8+ T cells.  |  Tong, X. 2023. Nat Metab. 5: 1850-1851. PMID: 37884693
5. Berberine protects mice against type 2 diabetes by promoting PPARγ-FGF21-GLUT2-regulated insulin sensitivity and glucose/lipid homeostasis.  |  Chen, Y., et al. 2023. Biochem Pharmacol. 218: 115928. PMID: 37979703
6. Molecular regulation of GLUT-4 targeting in 3T3-L1 adipocytes.  |  Marsh, BJ., et al. 1995. J Cell Biol. 130: 1081-91. PMID: 7544796
7. Regulation of glucose transporters in cultured rat adipocytes: synergistic effect of insulin and dexamethasone on GLUT4 gene expression through promoter activation.  |  Hajduch, E., et al. 1995. Endocrinology. 136: 4782-9. PMID: 7588207
8. Progressive hippocampal loss of immunoreactive GLUT3, the neuron-specific glucose transporter, after global forebrain ischemia in the rat.  |  McCall, AL., et al. 1995. Brain Res. 670: 29-38. PMID: 7719721
9. Expression and compartmentalization of caveolin in adipose cells: coordinate regulation with and structural segregation from GLUT4.  |  Kandror, KV., et al. 1995. J Cell Biol. 129: 999-1006. PMID: 7744970
10. Hypothalamic GLUT 4 expression: a glucose- and insulin-sensing mechanism?  |  Livingstone, C., et al. 1995. Mol Cell Endocrinol. 107: 67-70. PMID: 7796936
11. Facilitative glucose transporters.  |  Mueckler, M. 1994. Eur J Biochem. 219: 713-25. PMID: 8112322
12. Glucose transporters in the regulation of intestinal, renal, and liver glucose fluxes.  |  Thorens, B. 1996. Am J Physiol. 270: G541-53. PMID: 8928783

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Glucose Transporter Glut2 Antibody (C-10) has 24 citations in a variety of scientific publications.

Primary antibodies like Anti-Glucose Transporter Glut2 Antibody (C-10) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Glucose Transporter Glut2 Antibody (C-10) Specifications

Alternate Product Name: Glut2

Product Clone Name: C-10

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 32-98

Epitope Target: Glut2

Epitope Species: human

Product Reactivity/Detection: Glut2

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 24 citations in various scientific publications

Available Conjugates/Forms for Glucose Transporter Glut2 Antibody (C-10): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, B: Biotin, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin