GluR-δ1 Antibody (2B7): sc-81878

GluR-δ1 Antibody (2B7) is a mouse monoclonal IgG2b kappa light chain antibody that detects GluR-δ1 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). Anti-GluR-δ1 antibody (2B7) is available as the non-conjugated format. GluR-δ1 protein, also known as GRID1, is a multi-pass membrane protein that plays a crucial role in the central nervous system by regulating synaptic transmissions. GluR-δ1 is primarily localized at the postsynaptic cell membrane and cell junctions, where GluR-δ1 functions as a glutamate receptor, contributing to fast excitatory neurotransmission essential for neural communication. GluR-δ1 is particularly important for synaptic plasticity, a fundamental mechanism underlying learning and memory. Additionally, GluR-δ1 is implicated in various neurological disorders; defects in GluR-δ1 gene have been associated with schizophrenia, highlighting GluR-δ1′s significance in maintaining normal brain function. GluR-δ1′s ability to interact with other proteins in the glutamate receptor family further underscores GluR-δ1′s role in modulating synaptic activity and potential as a therapeutic target in neuropsychiatric conditions.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

GluR-δ1 Antibody (2B7) References:

1. Postsynaptic density-93 interacts with the delta2 glutamate receptor subunit at parallel fiber synapses.  |  Roche, KW., et al. 1999. J Neurosci. 19: 3926-34. PMID: 10234023
2. Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.  |  Nagase, T., et al. 1999. DNA Res. 6: 337-45. PMID: 10574462
3. Identification of rat EMAP, a delta-glutamate receptor binding protein.  |  Ly, CD., et al. 2002. Biochem Biophys Res Commun. 291: 85-90. PMID: 11829466
4. A novel protein complex linking the delta 2 glutamate receptor and autophagy: implications for neurodegeneration in lurcher mice.  |  Yue, Z., et al. 2002. Neuron. 35: 921-33. PMID: 12372286
5. Molecular cloning of a cDNA encoding a novel member of the mouse glutamate receptor channel family.  |  Yamazaki, M., et al. 1992. Biochem Biophys Res Commun. 183: 886-92. PMID: 1372507
6. Bipolar I disorder and schizophrenia: a 440-single-nucleotide polymorphism screen of 64 candidate genes among Ashkenazi Jewish case-parent trios.  |  Fallin, MD., et al. 2005. Am J Hum Genet. 77: 918-36. PMID: 16380905
7. A case-control association study between the GRID1 gene and schizophrenia in the Chinese Northern Han population.  |  Guo, SZ., et al. 2007. Schizophr Res. 93: 385-90. PMID: 17490860
8. Mapping of the mouse glutamate receptor delta1 subunit (Grid1) to chromosome 14.  |  Treadaway, J. and Zuo, J. 1998. Genomics. 54: 359-60. PMID: 9828146

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-GluR-δ1 Antibody (2B7) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-GluR-δ1 Antibody (2B7) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

GluR-δ1 Antibody (2B7) Specifications

Alternate Product Name: Glutamate receptor Delta type 1

Product Clone Name: 2B7

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2b kappa light chain

Amino Acids: 349-442

Epitope Target: GluR-δ1

Epitope Species: human

Product Reactivity/Detection: GluR-δ1

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, ELISA

Vialing Information: Each vial contains 100 µg IgG_2b kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for GluR-δ1 Antibody (2B7): N/A