Glomulin Antibody (YY-Z): sc-100752

Glomulin Antibody (YY-Z) is a mouse monoclonal IgG1 kappa light chain antibody that detects human Glomulin protein by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-Glomulin antibody (YY-Z) is available as non-conjugated format. Glomulin, also known as FKBP-associated protein (FAP), is essential for normal vascular system development, playing a pivotal role in vascular smooth muscle cell differentiation and vascular morphogenesis. Glomulin primarily localizes to the cell membrane, where Glomulin acts as a membrane-anchoring protein, facilitating interactions with other cellular components and influencing signaling pathways critical for vascular integrity and function. Proper Glomulin localization is vital, as disruptions can lead to glomuvenous malformations (GVMs), characterized by smooth muscle-like glomus cells in distended vascular lumens. The glomulin gene, located on chromosome 1p21-22, maintains vascular homeostasis, and complete loss of function results in GVM development. Glomulin exists in two isoforms, FAP48 and FAP68, which may have distinct roles in vascular biology.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

Glomulin Antibody (YY-Z) References:

1. Mutation of FKBP associated protein 48 (FAP48) at proline 219 disrupts the interaction with FKBP12 and FKBP52.  |  Neye, H. 2001. Regul Pept. 97: 147-52. PMID: 11164950
2. Ligand-regulated binding of FAP68 to the hepatocyte growth factor receptor.  |  Grisendi, S., et al. 2001. J Biol Chem. 276: 46632-8. PMID: 11571281
3. Mutations in a novel factor, glomulin, are responsible for glomuvenous malformations ('glomangiomas').  |  Brouillard, P., et al. 2002. Am J Hum Genet. 70: 866-74. PMID: 11845407
4. The FKBP-associated protein FAP48 is an antiproliferative molecule and a player in T cell activation that increases IL2 synthesis.  |  Krummrei, U., et al. 2003. Proc Natl Acad Sci U S A. 100: 2444-9. PMID: 12604780
5. Glomulin is predominantly expressed in vascular smooth muscle cells in the embryonic and adult mouse.  |  McIntyre, BA., et al. 2004. Gene Expr Patterns. 4: 351-8. PMID: 15053987
6. Glomuvenous malformation (glomangioma) and venous malformation: distinct clinicopathologic and genetic entities.  |  Boon, LM., et al. 2004. Arch Dermatol. 140: 971-6. PMID: 15313813
7. Four common glomulin mutations cause two thirds of glomuvenous malformations ('familial glomangiomas'): evidence for a founder effect.  |  Brouillard, P., et al. 2005. J Med Genet. 42: e13. PMID: 15689436

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Glomulin Antibody (YY-Z) has 1 citations in a variety of scientific publications.

Primary antibodies like Anti-Glomulin Antibody (YY-Z) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Glomulin Antibody (YY-Z) Specifications

Alternate Product Name: Glomulin

Product Clone Name: YY-Z

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 1-595

Epitope Target: Glomulin

Epitope Species: human

Product Reactivity/Detection: Glomulin

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 100 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 1 citations in various scientific publications

Available Conjugates/Forms for Glomulin Antibody (YY-Z): N/A