Gl Syn Antibody (D-6): sc-376767
- Gl Syn Antibody (D-6) is a mouse monoclonal IgG3 κ, cited in 2 publications, provided at 200 µg/ml
- specific for an epitope mapping between amino acids 61-101 near the N-terminus of Gl Syn of human origin
- recommended for detection of GI Syn of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA; also reactive with additional species, including and equine, canine, bovine and porcine
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for Gl Syn Antibody (D-6). This work is in progress.
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Gl Syn Antibody (D-6) is a mouse monoclonal IgG3 antibody that detects glutamine synthetase (Gl Syn) in mouse, rat, and human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). Glutamine synthetase (Gl Syn) plays a crucial role in the brain by catalyzing the conversion of glutamic acid to glutamine, a process vital for maintaining neurotransmitter balance and preventing excitotoxicity, which can lead to neuronal damage. Gl Syn (D-6) antibody targets an enzyme predominantly found in astrocytes, where Gl Syn expression is significantly induced upon contact with neurons, highlighting its importance in neuroprotection. Glutamine synthetase is also present in the liver, where Gl Syn contributes to nitrogen homeostasis, and Gl Syn overexpression has been associated with primary liver cancers, suggesting a potential role in hepatocyte transformation. Anti-Gl Syn antibody (D-6) serves as an essential tool for researchers studying glutamine synthetase dynamics in various physiological and pathological contexts, providing insights into Gl Syn function and interactions within the cellular environment.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Gl Syn Antibody (D-6) | sc-376767 | 200 µg/ml | $322.00 | |||
Gl Syn (D-6) Neutralizing Peptide | sc-376767 P | 100 µg/0.5 ml | $69.00 |