GIMAP5 Antibody (E-11): sc-377307

GIMAP5 Antibody (E-11) is a mouse monoclonal IgM antibody that detects GIMAP5 of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-GIMAP5 antibody (E-11) is available as the non-conjugated form. GIMAP5, also known as GTPase, IMAP family member 5, or IAN5 (immunity-associated nucleotide 5), is a 307 amino acid single-pass type IV membrane protein located in the mitochondrial outer membrane. GIMAP5 is a crucial member of the GTP-binding superfamily and the immuno-associated nucleotide (IAN) subfamily, playing a significant role in T-cell survival and maintaining mitochondrial integrity. GIMAP5 is predominantly expressed in CD4 and CD8-positive T-cells, monocytes, and B-lymphocyte-derived neoplasms, highlighting GIMAP5′s importance in immune responses. GIMAP5 exists in two alternatively spliced isoforms and is encoded by a gene located on human chromosome 7q36.1. Notably, defects in GIMAP5 have been linked to systemic lupus erythematosus, underscoring GIMAP5′s relevance in autoimmune diseases.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

GIMAP5 Antibody (E-11) References:

1. Molecular cloning of Ian4: a BCR/ABL-induced gene that encodes an outer membrane mitochondrial protein with GTP-binding activity.  |  Dahéron, L., et al. 2001. Nucleic Acids Res. 29: 1308-16. PMID: 11238997
2. Human ortholog to mouse gene imap38 encoding an ER-localizable G-protein belongs to a gene family clustered on chromosome 7q32-36.  |  Stamm, O., et al. 2002. Gene. 282: 159-67. PMID: 11814688
3. Comparative analysis of the human gimap gene cluster encoding a novel GTPase family.  |  Krücken, J., et al. 2004. Gene. 341: 291-304. PMID: 15474311
4. The human GIMAP5 gene has a common polyadenylation polymorphism increasing risk to systemic lupus erythematosus.  |  Hellquist, A., et al. 2007. J Med Genet. 44: 314-21. PMID: 17220214
5. Both Gimap5 and the diabetogenic BBDP allele of Gimap5 induce apoptosis in T cells.  |  Dalberg, U., et al. 2007. Int Immunol. 19: 447-53. PMID: 17369194
6. GIMAP5 regulates mitochondrial integrity from a distinct subcellular compartment.  |  Keita, M., et al. 2007. Biochem Biophys Res Commun. 361: 481-6. PMID: 17655828
7. IAN5 polymorphisms are associated with systemic lupus erythematosus.  |  Lim, MK., et al. 2009. Lupus. 18: 1045-52. PMID: 19762377
8. Loss of T cell and B cell quiescence precedes the onset of microbial flora-dependent wasting disease and intestinal inflammation in Gimap5-deficient mice.  |  Barnes, MJ., et al. 2010. J Immunol. 184: 3743-54. PMID: 20190135
9. Notch protection against apoptosis in T-ALL cells mediated by GIMAP5.  |  Chadwick, N., et al. 2010. Blood Cells Mol Dis. 45: 201-9. PMID: 20817506
10. GIMAP5 maintains liver endothelial cell homeostasis and prevents portal hypertension.  |  Drzewiecki, K., et al. 2021. J Exp Med. 218: PMID: 33956074
11. Gimap5 promoted RSV degradation through interaction with M6PR.  |  Dai, P., et al. 2023. J Med Virol. 95: e28390. PMID: 36484389
12. GIMAP5 deficiency reveals a mammalian ceramide-driven longevity assurance pathway.  |  Park, AY., et al. 2024. Nat Immunol. 25: 282-293. PMID: 38172257

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-GIMAP5 Antibody (E-11) has 1 citations in a variety of scientific publications.

Primary antibodies like Anti-GIMAP5 Antibody (E-11) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

GIMAP5 Antibody (E-11) Specifications

Alternate Product Name: GIMAP5

Product Clone Name: E-11

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgM kappa light chain

Amino Acids: 5-39

Epitope Target: GIMAP5

Epitope Species: human

Product Reactivity/Detection: GIMAP5

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgM kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 1 citations in various scientific publications

Available Conjugates/Forms for GIMAP5 Antibody (E-11): P: Blocking Peptide