GIGYF2 Antibody (A-12): sc-393918

GIGYF2 Antibody (A-12) is a mouse monoclonal IgG2b kappa light chain antibody that detects GIGYF2 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). GIGYF2 Antibody (A-12) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. GIGYF2, also known as GRB10 interacting GYF protein 2, GYF2, PERQ2, PERQ3, PARK11, or TNRC15, is a 1,299 amino acid protein that plays a crucial role in regulating tyrosine kinase receptor signaling, particularly for insulin-like growth factor 1 and insulin receptors. This regulation is vital for maintaining cellular homeostasis and metabolic functions, as dysregulation can lead to various diseases, including metabolic disorders and cancer. GIGYF2 is part of the PERQ family of proteins and features long stretches of glutamine and glutamic acid residues, which may influence interactions and functional properties. Notably, mutations in the GIGYF2 gene are implicated in Parkinson disease type 11 (PARK11), a neurodegenerative disorder characterized by bradykinesia, resting tremor, muscular rigidity, and postural instability, resulting from the loss of dopaminergic neurons in the substantia nigra. The presence of Lewy bodies, which are aggregates of misfolded proteins, further complicates the pathology of this disease. GIGYF2 exists as two alternatively spliced isoforms, adding another layer of complexity to functional roles in cellular signaling and disease mechanisms.

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GIGYF2 Antibody (A-12) References:

1. Mutations in the GIGYF2 (TNRC15) gene at the PARK11 locus in familial Parkinson disease.  |  Lautier, C., et al. 2008. Am J Hum Genet. 82: 822-33. PMID: 18358451
2. Lack of replication of association between GIGYF2 variants and Parkinson disease.  |  Bras, J., et al. 2009. Hum Mol Genet. 18: 341-6. PMID: 18923002
3. Haplotype analysis of the PARK 11 gene, GIGYF2, in sporadic Parkinson's disease.  |  Sutherland, GT., et al. 2009. Mov Disord. 24: 449-52. PMID: 19117363
4. PARK11 gene (GIGYF2) variants Asn56Ser and Asn457Thr are not pathogenic for Parkinson's disease.  |  Zimprich, A., et al. 2009. Parkinsonism Relat Disord. 15: 532-4. PMID: 19250854
5. Is GIGYF2 the defective gene at the PARK11 locus?  |  Bonifati, V. 2009. Curr Neurol Neurosci Rep. 9: 185-7. PMID: 19348706
6. GIGYF2 Asn56Ser mutation is rare in Chinese Parkinson's disease patients.  |  Zhang, Y., et al. 2009. Neurosci Lett. 463: 172-5. PMID: 19638301
7. Follow-up study of the GIGYF2 gene in French families with Parkinson's disease.  |  Lesage, S., et al. 2010. Neurobiol Aging. 31: 1069-71; discussion 1072-4. PMID: 20004041
8. Novel GIGYF2 gene variants in patients with Parkinson's disease in Chinese population.  |  Wang, L., et al. 2010. Neurosci Lett. 473: 131-5. PMID: 20178831

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-GIGYF2 Antibody (A-12) has 3 citations in a variety of scientific publications.

Primary antibodies like Anti-GIGYF2 Antibody (A-12) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

GIGYF2 Antibody (A-12) Specifications

Alternate Product Name: GIGYF2

Product Clone Name: A-12

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2b kappa light chain

Amino Acids: 1274-1297

Epitope Target: GIGYF2

Epitope Species: human

Product Reactivity/Detection: GIGYF2

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG_2b kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 3 citations in various scientific publications

Available Conjugates/Forms for GIGYF2 Antibody (A-12): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, P: Blocking Peptide, PE: Phycoerythrin