GGT5 Antibody (F-8): sc-373693

GGT5 Antibody (F-8) is a mouse monoclonal IgG1 antibody that detects GGT5 protein of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). GGT5 (F-8) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. The γ-glutamyltranspeptidase (GGT) family, which includes GGT5, plays a crucial role in glutathione metabolism, a key antioxidant in the body. GGT5 specifically catalyzes the conversion of leukotriene C4 to leukotriene D4, which is important in inflammatory responses and immune regulation. GGT5 is predominantly located on the outer surface of the cell membrane, facilitating involvement in the transfer of glutamyl moieties to various amino acids and dipeptides, thereby influencing cellular signaling and homeostasis. GGT5 exhibits a unique glycosylation pattern that contributes to functional diversity, and variations in this glycosylation can affect activity and interactions with other proteins. In clinical contexts, elevated GGT activity, including GGT5, can serve as a biomarker for liver diseases, making GGT5 a valuable target for research and diagnostic applications.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

GGT5 Antibody (F-8) References:

1. Identification of a human gamma-glutamyl cleaving enzyme related to, but distinct from, gamma-glutamyl transpeptidase.  |  Heisterkamp, N., et al. 1991. Proc Natl Acad Sci U S A. 88: 6303-7. PMID: 1676842
2. High-level expression of enzymatically active mature human gamma-glutamyltransferase in transgenic V79 Chinese hamster cells.  |  Visvikis, A., et al. 1991. Proc Natl Acad Sci U S A. 88: 7361-5. PMID: 1678521
3. The human gamma-glutamyltransferase gene family.  |  Heisterkamp, N., et al. 2008. Hum Genet. 123: 321-32. PMID: 18357469
4. The value of gamma-glutamyltransferase in cardiovascular risk prediction in men without diagnosed cardiovascular disease or diabetes.  |  Wannamethee, SG., et al. 2008. Atherosclerosis. 201: 168-75. PMID: 18378241
5. Serum elevated gamma glutamyltransferase levels may be a marker for oxidative stress in Alzheimer's disease.  |  Yavuz, BB., et al. 2008. Int Psychogeriatr. 20: 815-23. PMID: 18416873
6. Association of gamma-glutamyltransferase and risk of cancer incidence in men: a prospective study.  |  Strasak, AM., et al. 2008. Cancer Res. 68: 3970-7. PMID: 18483283
7. Assignment of the human gamma-glutamyl transferase gene to the long arm of chromosome 22.  |  Bulle, F., et al. 1987. Hum Genet. 76: 283-6. PMID: 2885259

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-GGT5 Antibody (F-8) has 1 citations in a variety of scientific publications.

Primary antibodies like Anti-GGT5 Antibody (F-8) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

GGT5 Antibody (F-8) Specifications

Alternate Product Name: GGT5

Product Clone Name: F-8

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ lambda light chain

Amino Acids: 161-395

Epitope Target: GGT5

Epitope Species: human

Product Reactivity/Detection: GGT5

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 200 µg IgG₁ lambda light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 1 citations in various scientific publications

Available Conjugates/Forms for GGT5 Antibody (F-8): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin