Gemin8 Antibody (B-6): sc-376518

Gemin8 Antibody (B-6) is a mouse monoclonal IgG2a antibody that detects Gemin8 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Gemin8 is a 242 amino acid protein encoded by the mouse gene Gemin8 and serves as a crucial component of the survival of motor neurons (SMN) complex, which is essential for the assembly of small nuclear ribonucleoproteins (snRNPs) that play a vital role in pre-mRNA splicing. The SMN complex, which includes Gemin8 along with Gemins 2-7 and unrip, acts as an assembly machine for snRNPs, and proper function is critical for maintaining neuronal health. Gemin8 directly binds to the SMN protein, facilitating interaction with the Gemin6/Gemin7 heterodimer, which is instrumental in organizing Sm proteins necessary for the formation of Sm rings on snRNA targets. Disruption of Gemin8 function can lead to impaired snRNP assembly, highlighting importance in the pathogenesis of spinal muscular atrophy, a neurodegenerative disease characterized by the loss of motor neurons. Gemin8 (B-6) antibody is an invaluable tool for researchers studying the SMN complex and implications in neurodegenerative disorders.

The preferred Gemin8 antibody is Gemin8 Antibody (1F8): sc-130669.