Gemin6 Antibody (20H8): sc-130667
- Gemin6 Antibody (20H8) is a mouse monoclonal IgG κ, cited in 2 publications, provided at 200 µg/ml
- raised against recombinant Gemin6 of human origin
- recommended for detection of Gemin6 of human origin by WB, IP and IF
- m-IgGκ BP-HRP is the preferred secondary detection reagent for Gemin6 Antibody (20H8) for WB applications. This reagent is now offered in a bundle with Gemin6 Antibody (20H8) (see ordering information below). For additional m-IgGκ BP conjugates see our complete list of Mouse IgG Binding Proteins.
Gemin6 Antibody (20H8) is a mouse monoclonal IgG antibody that detects Gemin6 in human samples through applications such as western blotting (WB), immunoprecipitation (IP), and immunofluorescence (IF). Gemin6, encoded by the human chromosome 2p22.2, plays a crucial role in the assembly of the SMN (Survival of Motor Neuron) complex, which is vital for the biogenesis of spliceosomal small nuclear ribonucleoproteins (snRNPs). This complex is essential for pre-mRNA splicing, a fundamental process in gene expression that ensures the correct maturation of mRNA before translation into proteins. The proper functioning of the SMN complex is particularly important in motor neurons, where dysfunction can lead to the neurodegenerative effects seen in spinal muscular atrophy (SMA). Gemin6 is localized in both the cytoplasm and nucleus, with significant concentration in subnuclear structures known as gems, which are critical for the assembly and storage of snRNPs. Anti-Gemin6 antibody (20H8) effectively detects this target in various applications, making Gemin6 (20H8) antibody an invaluable tool for researchers studying the molecular mechanisms underlying SMA and other related disorders.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Gemin6 Antibody (20H8) | sc-130667 | 200 µg/ml | $316.00 | |||
Gemin6 Antibody (20H8): m-IgGκ BP-HRP Bundle | sc-551074 | 200 µg Ab; 40 µg BP | $354.00 |