Gemin2 Antibody (4): sc-135918
- Gemin2 Antibody (4) is a mouse monoclonal IgG1 provided at 50 µg/0.5 ml
- raised against amino acids 36-156 of Gemin2 of human origin
- recommended for detection of Gemin2 of human origin by WB, IP and IF
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for Gemin2 Antibody (4). This work is in progress.
Gemin2 Antibody (4) is a mouse monoclonal IgG1 antibody that detects Gemin2 in human samples through applications such as western blotting (WB), immunoprecipitation (IP), and immunofluorescence (IF). Gemin2 plays a crucial role in the assembly of spliceosomal small nuclear ribonucleoproteins (snRNPs), which are essential for pre-mRNA splicing, a fundamental process in gene expression regulation. Gemin2 is primarily located in both the cytoplasm and nucleus, where Gemin2 is concentrated in subnuclear structures known as gems, or Gemini of coiled bodies. The presence of Gemin2 in these cellular compartments is vital for efficient assembly and function of the spliceosomal machinery, which is necessary for proper processing of pre-mRNA into mature mRNA. Additionally, Gemin2 interacts with several other proteins within the SMN complex, including SMN itself, Gemin3, Gemin4, Gemin5, and Gemin6, highlighting Gemin2′s importance in motor neuron function maintenance and potential implications in neurodegenerative diseases such as spinal muscular atrophy. Gemin2 expression can be induced by TGFβ treatment and is notably high in various E-cadherin negative human carcinoma cell lines, indicating Gemin2′s relevance in both normal cellular processes and pathological conditions. Anti-Gemin2 antibody (4) is an invaluable tool for researchers studying RNA splicing mechanisms and molecular underpinnings of related diseases.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Gemin2 Antibody (4) | sc-135918 | 50 µg/0.5 ml | $316.00 |