GDF-8 Antibody (1L4): sc-134345

GDF-8 Antibody (1L4) is a mouse monoclonal IgG2a kappa light chain antibody that detects GDF-8 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). Anti-GDF-8 antibody (1L4) is available as the non-conjugated format. GDF-8, also known as Myostatin, plays a crucial role in regulating skeletal muscle growth by inhibiting myoblast proliferation and differentiation, making GDF-8 a significant factor in muscle development and homeostasis. This negative regulatory function is particularly important in the context of muscle wasting conditions, where elevated levels of GDF-8 can contribute to muscle atrophy. Understanding GDF-8 mechanisms is vital for developing therapeutic strategies aimed at combating muscle degenerative diseases and enhancing muscle regeneration. As a member of the transforming growth factor-beta (TGF-β) superfamily, GDF-8′s interactions with other growth/differentiation factors underscore GDF-8′s importance in the intricate signaling pathways that govern muscle biology.

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GDF-8 Antibody (1L4) References:

1. Expression of growth/differentiation factor 1 in the nervous system: conservation of a bicistronic structure.  |  Lee, SJ. 1991. Proc Natl Acad Sci U S A. 88: 4250-4. PMID: 2034669
2. The transforming growth factor-beta family.  |  Massagué, J. 1990. Annu Rev Cell Biol. 6: 597-641. PMID: 2177343
3. Molecular characterization of latent GDF8 reveals mechanisms of activation.  |  Walker, RG., et al. 2018. Proc Natl Acad Sci U S A. 115: E866-E875. PMID: 29348202
4. Characterization of tolloid-mediated cleavage of the GDF8 procomplex.  |  McCoy, JC., et al. 2021. Biochem J. 478: 1733-1747. PMID: 33876824
5. GDF-8 stimulates trophoblast cell invasion by inducing ALK5-SMAD2/3-mediated MMP2 expression.  |  Fang, L., et al. 2021. Reproduction. 162: 331-338. PMID: 34432647
6. Regulatory Role and Potential Importance of GDF-8 in Ovarian Reproductive Activity.  |  Zheng, X., et al. 2022. Front Endocrinol (Lausanne). 13: 878069. PMID: 35692411
7. Snail mediates GDF-8-stimulated human extravillous trophoblast cell invasion by upregulating MMP2 expression.  |  Chen, J., et al. 2023. Cell Commun Signal. 21: 93. PMID: 37143106
8. GDF8 inhibition enhances musculoskeletal recovery and mitigates posttraumatic osteoarthritis following joint injury.  |  Brightwell, CR., et al. 2023. Sci Adv. 9: eadi9134. PMID: 38019905
9. Limb alterations in brachypodism mice due to mutations in a new member of the TGF beta-superfamily.  |  Storm, EE., et al. 1994. Nature. 368: 639-43. PMID: 8145850
10. GDF-3 and GDF-9: two new members of the transforming growth factor-beta superfamily containing a novel pattern of cysteines.  |  McPherron, AC. and Lee, SJ. 1993. J Biol Chem. 268: 3444-9. PMID: 8429021
11. Regulation of skeletal muscle mass in mice by a new TGF-beta superfamily member.  |  McPherron, AC., et al. 1997. Nature. 387: 83-90. PMID: 9139826
12. Growth/differentiation factor-5 induces angiogenesis in vivo.  |  Yamashita, H., et al. 1997. Exp Cell Res. 235: 218-26. PMID: 9281371

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-GDF-8 Antibody (1L4) has 13 citations in a variety of scientific publications.

Primary antibodies like Anti-GDF-8 Antibody (1L4) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

GDF-8 Antibody (1L4) Specifications

Alternate Product Name: GDF8

Product Clone Name: 1L4

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2a kappa light chain

Amino Acids: 243-310

Epitope Target: GDF-8

Epitope Species: human

Product Reactivity/Detection: GDF-8

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, ELISA

Vialing Information: Each vial contains 100 µg IgG_2a kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 13 citations in various scientific publications

Available Conjugates/Forms for GDF-8 Antibody (1L4): N/A

The preferred GDF-8/11 antibody is GDF-8/11 Antibody (H-9): sc-393335.