Molecular structure of GDC0994, CAS Number: 1453848-26-4
GDC0994 (CAS 1453848-26-4)
Alternate Names:
Ravoxertinib
CAS Number:
1453848-26-4
Molecular Weight:
440.87
Molecular Formula:
C21H18ClFN6O2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
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GDC0994 (CAS 1453848-26-4) References
- Discovery of (S)-1-(1-(4-Chloro-3-fluorophenyl)-2-hydroxyethyl)-4-(2-((1-methyl-1H-pyrazol-5-yl)amino)pyrimidin-4-yl)pyridin-2(1H)-one (GDC-0994), an Extracellular Signal-Regulated Kinase 1/2 (ERK1/2) Inhibitor in Early Clinical Development. | Blake, JF., et al. 2016. J Med Chem. 59: 5650-60. PMID: 27227380
- Specificity of Phosphorylation Responses to Mitogen Activated Protein (MAP) Kinase Pathway Inhibitors in Melanoma Cells. | Basken, J., et al. 2018. Mol Cell Proteomics. 17: 550-564. PMID: 29255136
- Study of the osteogenesis effect of icariside II and icaritin on canine bone marrow mesenchymal stem cells. | Luo, G., et al. 2018. J Bone Miner Metab. 36: 668-678. PMID: 29264750
- Novel Homodimer Metabolites of GDC-0994 via Cytochrome P450-Catalyzed Radical Coupling. | Takahashi, RH., et al. 2020. Drug Metab Dispos. 48: 521-527. PMID: 32234735
- Supervillin Contributes to LPS-induced Inflammatory Response in THP-1 Cell-derived Macrophages. | Zhou, J., et al. 2022. Inflammation. 45: 356-371. PMID: 34480249
- A proteomic signature and potential pharmacological opportunities in the adaptive resistance to MEK and PI3K kinase inhibition in pancreatic cancer cells. | Aguilar-Valdés, A., et al. 2023. Proteomics. 23: e2300041. PMID: 37140101
- Tetrandrine synergizes with MAPK inhibitors in treating KRAS-mutant pancreatic ductal adenocarcinoma via collaboratively modulating the TRAIL-death receptor axis. | Tang, S., et al. 2023. Pharmacol Res. 197: 106955. PMID: 37820855
- Psoralen and Isopsoralen, Two Estrogen-Like Natural Products from Psoraleae Fructus, Induced Cholestasis via Activation of ERK1/2. | Chen, LM., et al. 2024. Chem Res Toxicol. 37: 804-813. PMID: 38646980
- The ERK inhibitor GDC-0994 selectively inhibits growth of BRAF mutant cancer cells. | Chen, Y., et al. 2024. Transl Oncol. 45: 101991. PMID: 38728872
Inhibitor of:
E230008N13Rik, ERK 1, ERK 2, ERK 4, FLJ46321, MANBAL, Mxi 2, Olfr368, OTTMUSG00000011282, and PHTF2.Activator of:
ALY, and DUSP23.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
GDC0994, 10 mg | sc-507297 | 10 mg | $130.00 |