G_βL Antibody (E-9): sc-514982

GβL Antibody (E-9) is a mouse monoclonal IgG1 kappa light chain antibody that detects GβL protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). GβL (E-9) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. GβL protein, also known as mammalian lethal with SEC13 protein 8 (mLST8), plays a crucial role in regulating the mTOR signaling pathway, which is essential for cellular growth, proliferation, and survival. Through interactions with mTOR and other components of the signaling cascade, GβL helps modulate cellular response to nutrients and growth factors, making GβL vital for maintaining cellular homeostasis and influencing metabolic processes. Dysregulation of the mTOR pathway, where GβL plays a key role, has been implicated in various diseases, including cancer and metabolic disorders, highlighting the significance of studying GβL protein for therapeutic interventions.

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G_βL Antibody (E-9) References:

1. Insulin regulation of a novel WD-40 repeat protein in adipocytes.  |  Rodgers, BD., et al. 2001. J Endocrinol. 168: 325-32. PMID: 11182770
2. GbetaL, a positive regulator of the rapamycin-sensitive pathway required for the nutrient-sensitive interaction between raptor and mTOR.  |  Kim, DH., et al. 2003. Mol Cell. 11: 895-904. PMID: 12718876
3. Dissociation of raptor from mTOR is a mechanism of rapamycin-induced inhibition of mTOR function.  |  Oshiro, N., et al. 2004. Genes Cells. 9: 359-66. PMID: 15066126
4. Rheb binds and regulates the mTOR kinase.  |  Long, X., et al. 2005. Curr Biol. 15: 702-13. PMID: 15854902
5. Redox regulation of the nutrient-sensitive raptor-mTOR pathway and complex.  |  Sarbassov, DD. and Sabatini, DM. 2005. J Biol Chem. 280: 39505-9. PMID: 16183647

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-G_βL Antibody (E-9) has 1 citations in a variety of scientific publications.

Primary antibodies like Anti-G_βL Antibody (E-9) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

G_βL Antibody (E-9) Specifications

Alternate Product Name: MTOR associated protein, LST8 homolog

Product Clone Name: E-9

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 71-326

Epitope Target: G_βL

Epitope Species: human

Product Reactivity/Detection: G_βL

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 1 citations in various scientific publications

Available Conjugates/Forms for G_βL Antibody (E-9): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin