gamma Synuclein/SNCG Antibody (1H10D2): sc-65979

γ-synuclein Antibody (1H10D2) is a mouse monoclonal IgG1 kappa light chain antibody that detects γ-synuclein protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and immunohistochemistry. Anti-γ-synuclein antibody (1H10D2) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. γ-synuclein protein, also known as SNCG or BCSG1 (breast cancer-specific gene 1), is primarily localized in presynaptic terminals of neurons and plays a crucial role in synaptic regulation and neuronal plasticity. γ-synuclein (1H10D2) monoclonal antibody enables research into presynaptic functions, where γ-synuclein modulates neurotransmitter release and synaptic vesicle dynamics essential for proper neuronal communication. Dysregulation of γ-synuclein has been implicated in neurodegenerative diseases, including Parkinson′s disease, where γ-synuclein is associated with axonal pathology. Additionally, γ-synuclein′s interaction with other synucleins, such as alpha-synuclein, highlights γ-synuclein′s potential role in the pathophysiology of synucleinopathies, making γ-synuclein (1H10D2) antibody valuable for studying these critical processes in neurobiology.

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gamma Synuclein/SNCG Antibody (1H10D2) References:

1. Beta-synuclein displays an antiapoptotic p53-dependent phenotype and protects neurons from 6-hydroxydopamine-induced caspase 3 activation: cross-talk with alpha-synuclein and implication for Parkinson's disease.  |  da Costa, CA., et al. 2003. J Biol Chem. 278: 37330-5. PMID: 12867415
2. Degradative organelles containing mislocalized alpha-and beta-synuclein proliferate in presenilin-1 null neurons.  |  Wilson, CA., et al. 2004. J Cell Biol. 165: 335-46. PMID: 15123735
3. Beta-synuclein exhibits chaperone activity more efficiently than alpha-synuclein.  |  Lee, D., et al. 2004. FEBS Lett. 576: 256-60. PMID: 15474047
4. beta-Synuclein reduces proteasomal inhibition by alpha-synuclein but not gamma-synuclein.  |  Snyder, H., et al. 2005. J Biol Chem. 280: 7562-9. PMID: 15591046
5. Gamma-synuclein and the progression of cancer.  |  Ahmad, M., et al. 2007. FASEB J. 21: 3419-30. PMID: 17567567
6. Gamma-Synuclein Dysfunction Causes Autoantibody Formation in Glaucoma Patients and Dysregulation of Intraocular Pressure in Mice.  |  Pavlenko, TA., et al. 2022. Biomedicines. 11: PMID: 36672569
7. Substitution of Met-38 to Ile in γ-synuclein found in two patients with amyotrophic lateral sclerosis induces aggregation into amyloid.  |  Aubrey, LD., et al. 2024. Proc Natl Acad Sci U S A. 121: e2309700120. PMID: 38170745
8. The precursor protein of non-A beta component of Alzheimer's disease amyloid is a presynaptic protein of the central nervous system.  |  Iwai, A., et al. 1995. Neuron. 14: 467-75. PMID: 7857654
9. Identification of two distinct synucleins from human brain.  |  Jakes, R., et al. 1994. FEBS Lett. 345: 27-32. PMID: 8194594
10. Molecular cloning of cDNA encoding an unrecognized component of amyloid in Alzheimer disease.  |  Uéda, K., et al. 1993. Proc Natl Acad Sci U S A. 90: 11282-6. PMID: 8248242
11. Mutation in the alpha-synuclein gene identified in families with Parkinson's disease.  |  Polymeropoulos, MH., et al. 1997. Science. 276: 2045-7. PMID: 9197268
12. NACP, a synaptic protein involved in Alzheimer's disease, is differentially regulated during megakaryocyte differentiation.  |  Hashimoto, M., et al. 1997. Biochem Biophys Res Commun. 237: 611-6. PMID: 9299413

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-gamma Synuclein/SNCG Antibody (1H10D2) has 9 citations in a variety of scientific publications.

Primary antibodies like Anti-gamma Synuclein/SNCG Antibody (1H10D2) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

gamma Synuclein/SNCG Antibody (1H10D2) Specifications

Alternate Product Name: Synuclein Gamma

Product Clone Name: 1H10D2

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids:

Epitope Target: γ-synuclein

Epitope Species: human

Product Reactivity/Detection: γ-synuclein

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P)

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 9 citations in various scientific publications

Available Conjugates/Forms for gamma Synuclein/SNCG Antibody (1H10D2): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin