γ-catenin Antibody (B-7): sc-514130

γ-catenin Antibody (B-7) is a mouse monoclonal IgG3 antibody that detects γ-catenin in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). γ-catenin, also known as plakoglobin, plays a crucial role in cellular adhesion by forming complexes with cadherins, particularly in adherens junctions. γ-catenin (B-7) antibody targets proteins primarily located in the cytoplasm and cell membrane, where γ-catenin interacts with α-catenin and N-cadherin, facilitating structural integrity of tissues and influencing cell signaling pathways. γ-catenin′s location is essential for maintaining cell-cell adhesion and tissue architecture, which are vital for proper organ function and development. Additionally, γ-catenin′s association with tumor suppressor protein APC highlights a role in regulating cellular processes that, when disrupted, can lead to cancer progression. anti-γ-catenin antibody (B-7) serves as an invaluable tool for researchers studying cell adhesion dynamics and molecular mechanisms underlying various diseases.

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γ-catenin Antibody (B-7) References:

1. Dynamics of E-cadherin and gamma-catenin complexes during dedifferentiation of polarized MDCK cells.  |  Balkovetz, DF. and Sambandam, V. 1999. Kidney Int. 56: 910-21. PMID: 10469359
2. Mutations of the beta- and gamma-catenin genes are uncommon in human lung, breast, kidney, cervical and ovarian carcinomas.  |  Ueda, M., et al. 2001. Br J Cancer. 85: 64-8. PMID: 11437403
3. Inflammation-induced subcellular redistribution of VE-cadherin, actin, and gamma-catenin in cultured human lung microvessel endothelial cells.  |  Lim, MJ., et al. 2001. Microvasc Res. 62: 366-82. PMID: 11678639
4. Expression of non-membranous beta-catenin and gamma-catenin, c-Myc and cyclin D1 in relation to patient outcome in human colon adenocarcinomas.  |  Bondi, J., et al. 2004. APMIS. 112: 49-56. PMID: 14961975
5. Analysis of E-, N-cadherin, alpha-, beta-, and gamma-catenin expression in human pancreatic carcinoma cell lines.  |  Toyoda, E., et al. 2005. Pancreas. 30: 168-73. PMID: 15714139
6. Correlation of gamma-catenin expression with good prognosis in medulloblastomas.  |  Misaki, K., et al. 2005. J Neurosurg. 102: 197-206. PMID: 16156230
7. Adhesion molecules alpha, beta and gamma-catenin as prognostic factors of tumour progression in upper urinary tract urothelial tumours: the role of AKT-P/GSK-3beta/beta-catenin pathway.  |  Izquierdo, L., et al. 2009. BJU Int. 104: 100-6. PMID: 19154502
8. Immunohistochemical expression of NEDD9, E-cadherin and γ-catenin and their prognostic significance in pancreatic ductal adenocarcinoma (PDAC).  |  Radulović, P. and Krušlin, B. 2018. Bosn J Basic Med Sci. 18: 246-251. PMID: 29924959
9. E-cadherin and alpha-, beta-, and gamma-catenin protein expression in relation to metastasis in human breast carcinoma.  |  Bukholm, IK., et al. 1998. J Pathol. 185: 262-6. PMID: 9771479
10. Expression of E-cadherin, alpha-catenin, beta-catenin, and gamma-catenin in bronchioloalveolar carcinoma and conventional pulmonary adenocarcinoma: an immunohistochemical study.  |  Hidaka, N., et al. 1998. Mod Pathol. 11: 1039-45. PMID: 9831199

The preferred γ-catenin antibody is γ-catenin Antibody (A-6): sc-514115.