γ-catenin Antibody (11E4): sc-59986

γ-catenin Antibody (11E4) is a mouse monoclonal IgG1 antibody that detects γ-catenin in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), and immunofluorescence (IF). γ-catenin, also known as plakoglobin, plays a crucial role in cellular adhesion by forming complexes with cadherins, particularly in adherens junctions. γ-catenin is primarily located in the cytoplasm and at the cell membrane, where γ-catenin interacts with α-catenin and N-cadherin, facilitating structural integrity of tissues and influencing cell signaling pathways. γ-catenin′s location is essential for maintaining cell-cell adhesion and tissue architecture, which are vital for proper organ function and development. Additionally, γ-catenin′s interaction with other proteins, such as tumor suppressor APC, highlights γ-catenin′s role in cellular signaling and potential implications in cancer biology. Anti-γ-catenin antibody (11E4) enables researchers to gain valuable insights into cell adhesion dynamics and molecular mechanisms underlying various diseases.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

γ-catenin Antibody (11E4) References:

1. Reduced expression of alpha-catenin, beta-catenin, and gamma-catenin is associated with high cell proliferative activity and poor differentiation in non-small cell lung cancer.  |  Pirinen, RT., et al. 2001. J Clin Pathol. 54: 391-5. PMID: 11328840
2. Immunohistochemical analysis of gamma catenin in Wilms' tumors.  |  Basta-Jovanovic, G., et al. 2008. Fetal Pediatr Pathol. 27: 63-70. PMID: 18568994
3. Expression of β-catenin and γ-catenin in maxillary bone regeneration.  |  Santarelli, A., et al. 2011. Int J Immunopathol Pharmacol. 24: 107-11. PMID: 21781455
4. γ-Catenin is overexpressed in acute myeloid leukemia and promotes the stabilization and nuclear localization of β-catenin.  |  Morgan, RG., et al. 2013. Leukemia. 27: 336-43. PMID: 22858986
5. Desmoglein-3/γ-catenin and E-cadherin/ß-catenin differential expression in oral leukoplakia and squamous cell carcinoma.  |  Kyrodimou, M., et al. 2014. Clin Oral Investig. 18: 199-210. PMID: 23430339
6. Depletion of γ-catenin by Histone Deacetylase Inhibition Confers Elimination of CML Stem Cells in Combination with Imatinib.  |  Jin, Y., et al. 2016. Theranostics. 6: 1947-62. PMID: 27570562
7. FBW7 suppresses cell proliferation and G2/M cell cycle transition via promoting γ-catenin K63-linked ubiquitylation.  |  Li, Y., et al. 2018. Biochem Biophys Res Commun. 497: 473-479. PMID: 29408378
8. Dual β-Catenin and γ-Catenin Loss in Hepatocytes Impacts Their Polarity through Altered Transforming Growth Factor-β and Hepatocyte Nuclear Factor 4α Signaling.  |  Pradhan-Sundd, T., et al. 2021. Am J Pathol. 191: 885-901. PMID: 33662348
9. Expression of beta-catenin and gamma-catenin in epithelial tumor cell lines and characterization of a unique cell line.  |  Lipschutz, JH. and Kissil, JL. 1998. Cancer Lett. 126: 33-41. PMID: 9563646
10. The reduced expression of e-cadherin, alpha-catenin and gamma-catenin but not beta-catenin in human lung cancer.  |  Toyoyama, H., et al. 1999. Oncol Rep. 6: 81-5. PMID: 9864406

The preferred γ-catenin antibody is γ-catenin Antibody (A-6): sc-514115.