GALT Antibody (G-1): sc-365577

GALT Antibody (G-1) is a mouse monoclonal IgG1 kappa light chain antibody that detects GALT protein of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). GALT Antibody (G-1) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. GALT, or galactose-1-phosphate uridylyltransferase, is a crucial enzyme composed of 379 amino acids and belongs to the galactose-1-phosphate uridylyltransferase type 1 family. GALT primarily functions in the Leloir pathway of galactose metabolism, where GALT catalyzes the conversion of UDP-glucose and α-D-galactose 1-phosphate into α-D-glucose 1-phosphate and UDP-galactose. This reaction is vital as GALT not only facilitates energy production through glycolysis but also provides UDP-galactose, which serves as a galactosyl donor for the synthesis of essential glycoproteins and glycolipids. Proper functioning of GALT is critical for maintaining metabolic balance, and mutations in the GALT gene can lead to galactosemia, a serious metabolic disorder that can result in severe complications such as cataracts, mental retardation, and jaundice if not managed appropriately. In newborns, the inability to metabolize galactose can be life-threatening, underscoring the importance of GALT in human health.

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GALT Antibody (G-1) References:

1. Association of galactose-1-phosphate uridyltransferase activity and N314D genotype with the risk of ovarian cancer.  |  Goodman, MT., et al. 2002. Am J Epidemiol. 156: 693-701. PMID: 12370157
2. Mutations in galactose-1-phosphate uridyltransferase gene in patients with idiopathic presenile cataract.  |  Karas, N., et al. 2003. J Inherit Metab Dis. 26: 699-704. PMID: 14707519
3. [From gene to disease; galactosemia and galactose-1-phosphate uridyltransferase deficiency].  |  Bosch, AM., et al. 2004. Ned Tijdschr Geneeskd. 148: 80-1. PMID: 14753129
4. Molecular characterization of two galactosemia mutations and one polymorphism: implications for structure-function analysis of human galactose-1-phosphate uridyltransferase.  |  Reichardt, JK., et al. 1992. Biochemistry. 31: 5430-3. PMID: 1610789
5. Intracellular galactose-1-phosphate accumulation leads to environmental stress response in yeast model.  |  Slepak, T., et al. 2005. Mol Genet Metab. 86: 360-71. PMID: 16169270
6. Involvement of endoplasmic reticulum stress in a novel Classic Galactosemia model.  |  Slepak, TI., et al. 2007. Mol Genet Metab. 92: 78-87. PMID: 17643331
7. Cloning and characterization of a cDNA encoding human galactose-1-phosphate uridyl transferase.  |  Reichardt, JK. and Berg, P. 1988. Mol Biol Med. 5: 107-22. PMID: 2840550
8. Molecular basis of galactose-1-phosphate uridyltransferase deficiency involving skeletal muscle.  |  Ninfali, P., et al. 1996. J Neurol. 243: 102-3. PMID: 8869397

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-GALT Antibody (G-1) has 3 citations in a variety of scientific publications.

Primary antibodies like Anti-GALT Antibody (G-1) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

GALT Antibody (G-1) Specifications

Alternate Product Name: GALT

Product Clone Name: G-1

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 29-328

Epitope Target: GALT

Epitope Species: human

Product Reactivity/Detection: GALT

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 3 citations in various scientific publications

Available Conjugates/Forms for GALT Antibody (G-1): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin