G_{α s} Antibody (12): sc-135914

Gα s Antibody (12) is a mouse monoclonal IgG1 kappa light chain antibody designed to detect the Gα s subunit, also known as Gs alpha. Gα s monoclonal antibody (12) targets an epitope comprising amino acids 11-21 of the human Gα s protein, ensuring precise and reliable binding. The Gα s protein is a crucial component of heterotrimeric G proteins, featuring a distinct α-helical domain and a GTP-binding domain that are essential for its role in signal transduction. The structured ability of Gα s to bind and hydrolyze GTP allows Gα s to relay signals from cell surface receptors to intracellular effectors such as adenylyl cyclase, thereby regulating important physiological processes like hormone signaling, metabolism, and cellular growth. The integrity of Gα s′s structure is vital for maintaining accurate cellular communication, as any structural alterations can disrupt signaling pathways and contribute to various diseases. anti-Gα s antibody (12) exhibits broad species reactivity, effectively recognizing Gα s from mouse, rat, and human origins, making this reagent an invaluable tool for cross-species research applications. Gα s monoclonal antibody (12) is compatible with western blotting (WB) and immunoprecipitation (IP), enabling detailed analysis of G protein-mediated pathways. Available in both conjugated and non-conjugated forms, Gα s (12) antibody offers flexibility to meet diverse experimental needs.

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G_{α s} Antibody (12) References:

1. Different beta-subunits determine G-protein interaction with transmembrane receptors.  |  Kleuss, C., et al. 1992. Nature. 358: 424-6. PMID: 1322501
2. Selective tissue distribution of G protein gamma subunits, including a new form of the gamma subunits identified by cDNA cloning.  |  Cali, JJ., et al. 1992. J Biol Chem. 267: 24023-7. PMID: 1385432
3. G protein beta gamma subunits synthesized in Sf9 cells. Functional characterization and the significance of prenylation of gamma.  |  Iñiguez-Lluhi, JA., et al. 1992. J Biol Chem. 267: 23409-17. PMID: 1429682
4. Diversity among the beta subunits of heterotrimeric GTP-binding proteins: characterization of a novel beta-subunit cDNA.  |  von Weizsäcker, E., et al. 1992. Biochem Biophys Res Commun. 183: 350-6. PMID: 1543505
5. Gustducin is a taste-cell-specific G protein closely related to the transducins.  |  McLaughlin, SK., et al. 1992. Nature. 357: 563-9. PMID: 1608467
6. Diversity of G proteins in signal transduction.  |  Simon, MI., et al. 1991. Science. 252: 802-8. PMID: 1902986
7. G Protein Alpha S Subunit Promotes Cell Proliferation of Renal Cell Carcinoma with Involvement of Protein Kinase A Signaling.  |  Zhang, B., et al. 2017. DNA Cell Biol. 36: 237-242. PMID: 28051330
8. Maternal GNAS Contributes to the Extra-Large G Protein α-Subunit (XLαs) Expression in a Cell Type-Specific Manner.  |  Cui, Q., et al. 2021. Front Genet. 12: 680537. PMID: 34220953
9. Beyond the G protein α subunit: investigating the functional impact of other components of the Gαi3 heterotrimers.  |  Rysiewicz, B., et al. 2023. Cell Commun Signal. 21: 279. PMID: 37817242
10. Selectivity in signal transduction determined by gamma subunits of heterotrimeric G proteins.  |  Kleuss, C., et al. 1993. Science. 259: 832-4. PMID: 8094261
11. Structural elements of G alpha subunits that interact with G beta gamma, receptors, and effectors.  |  Conklin, BR. and Bourne, HR. 1993. Cell. 73: 631-41. PMID: 8388779
12. Golf: an olfactory neuron specific-G protein involved in odorant signal transduction.  |  Jones, DT. and Reed, RR. 1989. Science. 244: 790-5. PMID: 2499043

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-G_{α s} Antibody (12) has 13 citations in a variety of scientific publications.

Primary antibodies like Anti-G_{α s} Antibody (12) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

G_{α s} Antibody (12) Specifications

Alternate Product Name: G protein subunit GNAS

Product Clone Name: 12

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 11-21

Epitope Target: G_{α s}

Epitope Species: human

Product Reactivity/Detection: G_{α s}

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 13 citations in various scientific publications

Available Conjugates/Forms for G_{α s} Antibody (12): AC: Agarose, HRP: Horseradish Peroxidase