G alpha q/11 Antibody (F-5): sc-515689
- Gα q/11 Antibody (F-5) is a mouse monoclonal IgG2b κ, cited in 6 publications, provided at 200 µg/ml
- specific for an epitope mapping between amino acids 179-199 within an internal region of Gα 11 of human origin
- recommended for detection of Gα q and Gα11 of mouse, rat and human origin by WB, IP, IF and ELISA
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for Gα q/11 Antibody (F-5). This work is in progress.
Gα q/11 Antibody (F-5) is a mouse monoclonal IgG2b antibody that detects Gα q/11 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Gα q/11 is a crucial member of the heterotrimeric G protein family, which plays a vital role in transmitting signals from various cell surface receptors to intracellular effectors, thereby influencing numerous physiological processes. Specifically, Gα q/11 is involved in the activation of phospholipase C, leading to the production of inositol trisphosphate and diacylglycerol, which are essential for calcium signaling and the activation of protein kinase C. This signaling pathway is particularly important in the context of cardiovascular function, neuronal signaling, and immune responses, as Gα q/11 regulates various cellular activities such as muscle contraction, neurotransmitter release, and cell proliferation. Gα q/11 is predominantly located in the plasma membrane, where Gα q/11 interacts with a variety of receptors, including those for hormones and neurotransmitters, making Gα q/11 a key player in mediating extracellular signals. anti-Gα q/11 antibody (F-5) is an invaluable tool for researchers aiming to explore the intricate signaling mechanisms involving G proteins and their implications in health and disease.
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G alpha q/11 Antibody (F-5) References:
- Selective regulation of Galpha(q/11) by an RGS domain in the G protein-coupled receptor kinase, GRK2. | Carman, CV., et al. 1999. J Biol Chem. 274: 34483-92. PMID: 10567430
- Administration of antisense oligonucleotides to Galpha(Q/11) reduces the severity of murine lupus. | Ansari, MA., et al. 2003. Biochimie. 85: 627-32. PMID: 12829380
- Gender differences and hormonal modulation of G proteins Galpha(q/11) expression in lymphoid organs. | Morton, TL., et al. 2003. Neuroendocrinology. 78: 147-53. PMID: 14512707
- Gα(q/11) signaling tonically modulates nociceptor function and contributes to activity-dependent sensitization. | Tappe-Theodor, A., et al. 2012. Pain. 153: 184-196. PMID: 22071319
- Shear stress induces Gαq/11 activation independently of G protein-coupled receptor activation in endothelial cells. | Dela Paz, NG., et al. 2017. Am J Physiol Cell Physiol. 312: C428-C437. PMID: 28148497
- Rapid flow-induced activation of Gαq/11 is independent of Piezo1 activation. | Dela Paz, NG. and Frangos, JA. 2019. Am J Physiol Cell Physiol. 316: C741-C752. PMID: 30811222
- Functional activation of Gαq/11 protein via α1 -adrenoceptor in rat cerebral cortical membranes. | Odagaki, Y., et al. 2019. Clin Exp Pharmacol Physiol. 46: 567-574. PMID: 30869808
- Uterine Gαq/11 signaling, in a progesterone-dependent manner, critically regulates the acquisition of uterine receptivity in the female mouse. | de Oliveira, V., et al. 2019. FASEB J. 33: 9374-9387. PMID: 31091422
- 5-HT2A receptor-mediated Gαq/11 activation in psychiatric disorders: A postmortem study. | Odagaki, Y., et al. 2021. World J Biol Psychiatry. 22: 505-515. PMID: 33084439
- Targeting Oncogenic Gαq/11 in Uveal Melanoma. | Lapadula, D. and Benovic, JL. 2021. Cancers (Basel). 13: PMID: 34944815
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Gα q/11 Antibody (F-5) | sc-515689 | 200 µg/ml | $322.00 |