galectin-8 Antibody (C-8): sc-377133
- galectin-8 Antibody (C-8) is a mouse monoclonal IgG1 κ galectin-8 antibody, cited in 6 publications, provided at 200 µg/ml
- raised against amino acids 141-220 mapping within an internal region of galectin-8 of human origin
- galectin-8 Antibody (C-8) is recommended for detection of galectin-8 of human origin by WB, IP, IF and ELISA
- Anti-galectin-8 Antibody (C-8) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP is the preferred secondary detection reagent for galectin-8 Antibody (C-8) for WB applications. This reagent is now offered in a bundle with galectin-8 Antibody (C-8) (see ordering information below).
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SEE ALSO...
galectin-8 Antibody (C-8) is a mouse monoclonal IgG1 kappa light chain antibody that detects galectin-8 protein of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). anti-galectin-8 antibody (C-8) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. galectin-8, also known as prostate-specific membrane antigen (PCTA-1), plays a crucial role in mediating cell-cell and cell-matrix interactions, which are essential for maintaining tissue architecture and facilitating cellular communication. galectin-8 (PCTA-1) is particularly significant in prostate cancer, as expression occurs exclusively in malignant tumors, making galectin-8 a more specific biomarker compared to other prostate-specific antigens like prostate-specific antigen (PSA), which can also be elevated in benign conditions. This unique expression pattern not only aids in prostate cancer diagnosis but also provides insights into molecular mechanisms underlying tumor progression and metastasis. Using galectin-8 monoclonal antibody (C-8) in research can enhance understanding of galectin-8′s role in cancer biology and potentially contribute to targeted therapy development.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
galectin-8 Antibody (C-8) References:
- The N-terminal carbohydrate recognition domain of galectin-8 recognizes specific glycosphingolipids with high affinity. | Ideo, H., et al. 2003. Glycobiology. 13: 713-23. PMID: 12851289
- Galectin-8 modulates neutrophil function via interaction with integrin alphaM. | Nishi, N., et al. 2003. Glycobiology. 13: 755-63. PMID: 12881409
- Role of galectin-8 as a modulator of cell adhesion and cell growth. | Zick, Y., et al. 2002. Glycoconj J. 19: 517-26. PMID: 14758075
- Human galectin-8 isoforms and cancer. | Bidon-Wagner, N. and Le Pennec, JP. 2002. Glycoconj J. 19: 557-63. PMID: 14758080
- Tissue concentrations of prostate-specific antigen in prostatic carcinoma and benign prostatic hyperplasia. | Pretlow, TG., et al. 1991. Int J Cancer. 49: 645-9. PMID: 1718912
- Galectin-8 in the onset of the immune response and inflammation. | Tribulatti, MV., et al. 2020. Glycobiology. 30: 134-142. PMID: 31529033
- Galectin-8 alters immune microenvironment and promotes tumor progression. | Wang, Y., et al. 2023. Am J Cancer Res. 13: 2517-2529. PMID: 37424827
- Hypoxia-induced galectin-8 maintains stemness in glioma stem cells via autophagy regulation. | Liu, D., et al. 2024. Neuro Oncol. 26: 872-888. PMID: 38158714
- Discovery of galectin-8 as an LILRB4 ligand driving M-MDSCs defines a class of antibodies to fight solid tumors. | Wang, Y., et al. 2024. Cell Rep Med. 5: 101374. PMID: 38232701
- Molecular cloning of a complementary DNA encoding a prostate-specific membrane antigen. | Israeli, RS., et al. 1993. Cancer Res. 53: 227-30. PMID: 8417812
- Surface-epitope masking and expression cloning identifies the human prostate carcinoma tumor antigen gene PCTA-1 a member of the galectin gene family. | Su, ZZ., et al. 1996. Proc Natl Acad Sci U S A. 93: 7252-7. PMID: 8692978
- Two differentially expressed genes in normal human prostate tissue and in carcinoma. | Wang, FL., et al. 1996. Cancer Res. 56: 3634-7. PMID: 8705997
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
galectin-8 Antibody (C-8) | sc-377133 | 200 µg/ml | $322.00 | |||
galectin-8 Antibody (C-8): m-IgG Fc BP-HRP Bundle | sc-526081 | 200 µg Ab; 10 µg BP | $361.00 | |||
galectin-8 Antibody (C-8) AC | sc-377133 AC | 500 µg/ml, 25% agarose | $424.00 | |||
galectin-8 Antibody (C-8) HRP | sc-377133 HRP | 200 µg/ml | $322.00 | |||
galectin-8 Antibody (C-8) FITC | sc-377133 FITC | 200 µg/ml | $336.00 | |||
galectin-8 Antibody (C-8) PE | sc-377133 PE | 200 µg/ml | $349.00 | |||
galectin-8 Antibody (C-8) Alexa Fluor® 488 | sc-377133 AF488 | 200 µg/ml | $364.00 | |||
galectin-8 Antibody (C-8) Alexa Fluor® 546 | sc-377133 AF546 | 200 µg/ml | $364.00 | |||
galectin-8 Antibody (C-8) Alexa Fluor® 594 | sc-377133 AF594 | 200 µg/ml | $364.00 | |||
galectin-8 Antibody (C-8) Alexa Fluor® 647 | sc-377133 AF647 | 200 µg/ml | $364.00 | |||
galectin-8 Antibody (C-8) Alexa Fluor® 680 | sc-377133 AF680 | 200 µg/ml | $364.00 | |||
galectin-8 Antibody (C-8) Alexa Fluor® 790 | sc-377133 AF790 | 200 µg/ml | $364.00 |