galectin-7 Antibody (A-8): sc-271473
- galectin-7 Antibody (A-8) is a mouse monoclonal IgG3 κ provided at 200 µg/ml
- specific for an epitope mapping between amino acids 41-91 within an internal region of galectin-7 of human origin
- recommended for detection of galectin-7 of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA
- m-IgG3 BP-HRP is the preferred secondary detection reagent for galectin-7 Antibody (A-8) for WB and IHC(P) applications. This reagent is now offered in a bundle with galectin-7 Antibody (A-8) (see ordering information below).
QUICK LINKS
SEE ALSO...
galectin-7 Antibody (A-8) is a mouse monoclonal IgG3 antibody that detects galectin-7 in mouse, rat, and human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). Galectin-7 is a member of the galectin family, which consists of soluble β-galactoside-binding lectins that play crucial roles in cellular processes such as cell adhesion, apoptosis, and tumor progression. anti-galectin-7 antibody (A-8) targets a protein predominantly expressed in stratified squamous epithelium and known for pro-apoptotic function, acting upstream of c-Jun N-terminal kinase (JNK) activation and cytochrome c release, which are vital for the apoptotic signaling pathway. Galectin-7 regulation is tightly controlled, activated by the tumor suppressor protein p53 and repressed by retinoic acid, highlighting galectin-7′s importance in maintaining cellular homeostasis and responding to stress signals. The galectin-7 gene is located on chromosome 19, and galectin-7 expression is critical for various physiological and pathological processes, making galectin-7 (A-8) monoclonal antibody an essential tool for researchers studying apoptosis and cancer biology.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
galectin-7 Antibody (A-8) References:
- Galectin-7 in the control of epidermal homeostasis after injury. | Gendronneau, G., et al. 2008. Mol Biol Cell. 19: 5541-9. PMID: 18829868
- Expression and functions of galectin-7 in human and murine melanomas. | Biron-Pain, K., et al. 2013. PLoS One. 8: e63307. PMID: 23658821
- E-cadherin dynamics is regulated by galectin-7 at epithelial cell surface. | Advedissian, T., et al. 2017. Sci Rep. 7: 17086. PMID: 29213102
- Galectin-7 promotes proliferation and Th1/2 cells polarization toward Th1 in activated CD4+ T cells by inhibiting The TGFβ/Smad3 pathway. | Luo, Z., et al. 2018. Mol Immunol. 101: 80-85. PMID: 29890367
- Paeoniflorin inhibits proliferation and migration of psoriatic keratinocytes via the lncRNA NEAT1/miR-3194-5p/Galectin-7 axis. | Wang, D., et al. 2022. Anticancer Drugs. 33: e423-e433. PMID: 34459454
- CCCTC-binding factor transcriptionally regulates Galectin-7 and activates the JNK/STAT3 axis to aggravate bronchial epithelial cell injury. | Sun, X., et al. 2022. Pediatr Pulmonol. 57: 90-99. PMID: 34643340
- Human Galectin-7 Gene LGALS7 Promoter Sequence Polymorphisms and Risk of Spontaneous Intracerebral Hemorrhage: A Prospective Study. | Wang, MD., et al. 2022. Front Mol Neurosci. 15: 840340. PMID: 35401111
- Expression and prongostic impact of galectin-7 in human lung cancer. | Tirilomi, A., et al. 2024. Medicine (Baltimore). 103: e39911. PMID: 39465762
- Targeting the Galectin-7/TRPM2/Zn2+/DRP-1 Signaling Pathway: A Potential Therapeutic Intervention in the Pathogenesis of SJS/TEN. | Zhang, C., et al. 2025. Allergy.. PMID: 40042066
- Galectin-7, a marker of all types of stratified epithelia. | Magnaldo, T., et al. 1998. Differentiation. 63: 159-68. PMID: 9697310
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
galectin-7 Antibody (A-8) | sc-271473 | 200 µg/ml | $322.00 | |||
galectin-7 Antibody (A-8): m-IgG3 BP-HRP Bundle | sc-550406 | 200 µg Ab; 40 µg BP | $361.00 | |||
galectin-7 (A-8) Neutralizing Peptide | sc-271473 P | 100 µg/0.5 ml | $69.00 |