GALE Antibody (D-11): sc-390460

GALE Antibody (D-11) is a mouse monoclonal IgG2b antibody that detects GALE in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). GALE, also known as galactowaldenase, UDP-galactose-4-epimerase, or SDR1E1, is a 348 amino acid protein that plays a crucial role as the third enzyme in the Leloir pathway of galactose metabolism. This pathway is essential for the proper utilization of galactose, a sugar that is vital for various biological processes, including energy production and the synthesis of glycoproteins and glycolipids. GALE functions as a homodimer and requires FAD as a cofactor to catalyze the epimerization of UDP-N-acetylglucosamine to UDP-N-acetylgalactosamine and UDP-glucose to UDP-galactose. The gene encoding GALE is located on human chromosome 1p36.11, and mutations in this gene can lead to epimerase-deficiency galactosemia (EDG), a complex disorder characterized by severe symptoms such as mental retardation, liver damage, cataracts, and deafness. GALE (D-11) antibody is an invaluable tool for researchers studying galactose metabolism and its associated disorders, providing insights into GALE′s function and implications in human health.

The preferred GALE antibody is GALE Antibody (C-4): sc-390407.