Galactose Mutarotase Antibody (H-7): sc-166304

Galactose Mutarotase Antibody (H-7) is a mouse monoclonal IgG1 kappa light chain antibody that detects Galactose Mutarotase protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). Galactose Mutarotase (H-7) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. Galactose Mutarotase is a crucial enzyme in the aldose epimerase family, playing a significant role in hexose metabolism by catalyzing the conversion of β-D-galactose to α-D-galactose, which is essential for proper galactose metabolism. This enzyme is predominantly located in the cytoplasm of most cells, where Galactose Mutarotase facilitates the interconversion of different sugar forms, thereby influencing energy production and cellular function. Galactose Mutarotase activity is vital for maintaining normal metabolic processes, as any disruption could lead to an accumulation of unmetabolized sugars, potentially resulting in metabolic disorders. The catalytic mechanism of Galactose Mutarotase involves critical residues such as Glu 304 and His 170, which are essential for enzymatic function, while His 96 and Asp 243 play important roles in substrate recognition. Understanding Galactose Mutarotase function and importance is crucial for elucidating metabolic pathway roles and potential implications in health and disease.

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Galactose Mutarotase Antibody (H-7) References:

1. Galactose mutarotase: pH dependence of enzymatic mutarotation.  |  Beebe, JA., et al. 2003. Biochemistry. 42: 4414-20. PMID: 12693937
2. The catalytic mechanism of galactose mutarotase.  |  Thoden, JB., et al. 2003. Protein Sci. 12: 1051-9. PMID: 12717027
3. Molecular structure of human galactose mutarotase.  |  Thoden, JB., et al. 2004. J Biol Chem. 279: 23431-7. PMID: 15026423
4. Ribose utilization with an excess of mutarotase causes cell death due to accumulation of methylglyoxal.  |  Kim, I., et al. 2004. J Bacteriol. 186: 7229-35. PMID: 15489434
5. The molecular architecture of galactose mutarotase/UDP-galactose 4-epimerase from Saccharomyces cerevisiae.  |  Thoden, JB. and Holden, HM. 2005. J Biol Chem. 280: 21900-7. PMID: 15795221
6. Structural insights into the monosaccharide specificity of Escherichia coli rhamnose mutarotase.  |  Ryu, KS., et al. 2005. J Mol Biol. 349: 153-62. PMID: 15876375
7. Identification of a gene cluster for the formation of extracellular polysaccharide precursors in the chemolithoautotroph Acidithiobacillus ferrooxidans.  |  Barreto, M., et al. 2005. Appl Environ Microbiol. 71: 2902-9. PMID: 15932984
8. New synchrotron radiation circular dichroism end-station on DISCO beamline at SOLEIL synchrotron for biomolecular analysis.  |  Miron, S., et al. 2005. Biochim Biophys Acta. 1724: 425-31. PMID: 16026934
9. Galactose mutarotase: purification, characterization, and investigations of two important histidine residues.  |  Beebe, JA. and Frey, PA. 1998. Biochemistry. 37: 14989-97. PMID: 9778377

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Galactose Mutarotase Antibody (H-7) has 1 citations in a variety of scientific publications.

Primary antibodies like Anti-Galactose Mutarotase Antibody (H-7) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Galactose Mutarotase Antibody (H-7) Specifications

Alternate Product Name: Galactose Mutarotase

Product Clone Name: H-7

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 300-319

Epitope Target: Galactose Mutarotase

Epitope Species: human

Product Reactivity/Detection: Galactose Mutarotase

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 1 citations in various scientific publications

Available Conjugates/Forms for Galactose Mutarotase Antibody (H-7): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, P: Blocking Peptide, PE: Phycoerythrin