GAIP Antibody (C-11): sc-365156

GAIP Antibody (C-11) is a mouse monoclonal IgG2b antibody that detects GAIP in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). GAIP, or Gα-interacting protein, plays a crucial role in the regulation of G protein signaling pathways by acting as a GTPase-activating protein (GAP) specifically for certain Gα subunits. This regulation is vital for maintaining cellular homeostasis and ensuring proper signal transduction, as GAIP enhances the hydrolysis of GTP to GDP, effectively turning off the signaling cascade initiated by G protein-coupled receptors. The ability of GAIP to selectively deactivate Gα i, Gα o, and Gα t isoforms, while sparing Gα s, underscores GAIP′s importance in fine-tuning cellular responses to external stimuli. By modulating the activity of these G proteins, GAIP influences various physiological processes, including cell growth, differentiation, and migration, making GAIP a significant player in both normal cellular function and disease states. Anti-GAIP antibody (C-11) is an essential tool for researchers aiming to explore the intricate dynamics of G protein signaling and its implications in health and disease.

The preferred GAIP antibody is GAIP Antibody (B-6): sc-271810.