GAIP Antibody (B-6): sc-271810

GAIP Antibody (B-6) is a mouse monoclonal IgG3 kappa light chain antibody that detects GAIP protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-GAIP antibody (B-6) is available as the non-conjugated form. GAIP protein plays a crucial role in regulating G protein signaling pathways, which are essential for transmitting signals from cell surface receptors to various intracellular effectors. GAIP functions as a GTPase-activating protein (GAP) that enhances GTP to GDP hydrolysis on specific Gα subunits, thereby inactivating them and modulating signaling activity. This regulation is vital for maintaining cellular homeostasis and ensuring appropriate responses to external stimuli. GAIP has been shown to interact with Gα i, Gα o, and Gα t isoforms, but not with Gα s, highlighting specificity in G protein signaling. GAIP′s ability to deactivate these Gα isoforms helps control processes such as cell proliferation, differentiation, and apoptosis, making GAIP an important target for research in various physiological and pathological contexts.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

GAIP Antibody (B-6) References:

1. Different beta-subunits determine G-protein interaction with transmembrane receptors.  |  Kleuss, C., et al. 1992. Nature. 358: 424-6. PMID: 1322501
2. Selective tissue distribution of G protein gamma subunits, including a new form of the gamma subunits identified by cDNA cloning.  |  Cali, JJ., et al. 1992. J Biol Chem. 267: 24023-7. PMID: 1385432
3. Diversity among the beta subunits of heterotrimeric GTP-binding proteins: characterization of a novel beta-subunit cDNA.  |  von Weizsäcker, E., et al. 1992. Biochem Biophys Res Commun. 183: 350-6. PMID: 1543505
4. Gustducin is a taste-cell-specific G protein closely related to the transducins.  |  McLaughlin, SK., et al. 1992. Nature. 357: 563-9. PMID: 1608467
5. Diversity of G proteins in signal transduction.  |  Simon, MI., et al. 1991. Science. 252: 802-8. PMID: 1902986
6. Structural elements of G alpha subunits that interact with G beta gamma, receptors, and effectors.  |  Conklin, BR. and Bourne, HR. 1993. Cell. 73: 631-41. PMID: 8388779
7. RGS family members: GTPase-activating proteins for heterotrimeric G-protein alpha-subunits.  |  Watson, N., et al. 1996. Nature. 383: 172-5. PMID: 8774882
8. RGS10 is a selective activator of G alpha i GTPase activity.  |  Hunt, TW., et al. 1996. Nature. 383: 175-7. PMID: 8774883

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-GAIP Antibody (B-6) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-GAIP Antibody (B-6) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

GAIP Antibody (B-6) Specifications

Alternate Product Name: GAIP

Product Clone Name: B-6

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₃ kappa light chain

Amino Acids: 189-216

Epitope Target: GAIP

Epitope Species: human

Product Reactivity/Detection: GAIP

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG₃ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for GAIP Antibody (B-6): P: Blocking Peptide