G0S2 Antibody (D-1): sc-518067

G0S2 Antibody (D-1) is a mouse monoclonal IgG1 kappa light chain antibody that detects G0S2 protein of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). G0S2 (D-1) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. G0S2, also known as putative lymphocyte G0/G1 switch protein 2, plays a crucial role in regulating cell cycle progression, particularly in the transition from G0 phase to G1 phase, which is essential for cellular proliferation and differentiation. This regulation is particularly important in adipocyte differentiation, where G0S2 expression is necessary for cells to commit to entering the cell cycle, thereby influencing metabolic processes and energy homeostasis. Additionally, G0S2 is a novel target of peroxisome proliferator-activated receptors (PPARs) and has been implicated in the regulation of latent HIV, highlighting potential significance in both metabolic and viral pathologies. The gene encoding G0S2 is located on human chromosome 1, the largest chromosome in the human genome, which spans approximately 260 million base pairs and contains around 3,000 genes. Given the extensive number of genes on chromosome 1, G0S2 is associated with a variety of diseases, including rare conditions like Hutchinson-Gilford progeria and several cancers, making G0S2 a protein of considerable interest in both basic and clinical research.

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G0S2 Antibody (D-1) References:

1. Gaucher disease and parkinsonism: a phenotypic and genotypic characterization.  |  Tayebi, N., et al. 2001. Mol Genet Metab. 73: 313-21. PMID: 11509013
2. Identification of risk and age-at-onset genes on chromosome 1p in Parkinson disease.  |  Oliveira, SA., et al. 2005. Am J Hum Genet. 77: 252-64. PMID: 15986317
3. The G0/G1 switch gene 2 is a novel PPAR target gene.  |  Zandbergen, F., et al. 2005. Biochem J. 392: 313-24. PMID: 16086669
4. G0S2 is an all-trans-retinoic acid target gene.  |  Kitareewan, S., et al. 2008. Int J Oncol. 33: 397-404. PMID: 18636162
5. Analysis of the vitreous membrane in a case of type 1 Stickler syndrome.  |  Yokoi, T., et al. 2009. Graefes Arch Clin Exp Ophthalmol. 247: 715-8. PMID: 19089441
6. A human putative lymphocyte G0/G1 switch gene containing a CpG-rich island encodes a small basic protein with the potential to be phosphorylated.  |  Russell, L. and Forsdyke, DR. 1991. DNA Cell Biol. 10: 581-91. PMID: 1930693
7. Gain of chromosome arm 1q in patients in relapse and progression of multiple myeloma.  |  Balcárková, J., et al. 2009. Cancer Genet Cytogenet. 192: 68-72. PMID: 19596256
8. G0S2 inhibits the proliferation of K562 cells by interacting with nucleolin in the cytosol.  |  Yamada, T., et al. 2014. Leuk Res. 38: 210-7. PMID: 24183236
9. Single-Cell Sequencing Analysis and Multiple Machine Learning Methods Identified G0S2 and HPSE as Novel Biomarkers for Abdominal Aortic Aneurysm.  |  Xiong, T., et al. 2022. Front Immunol. 13: 907309. PMID: 35769488
10. G0S2 promotes antiestrogenic and pro-migratory responses in ER+ and ER- breast cancer cells.  |  Corbet, AK., et al. 2023. Transl Oncol. 33: 101676. PMID: 37086619
11. Cyclosporin A inhibits early mRNA expression of G0/G1 switch gene 2 (G0S2) in cultured human blood mononuclear cells.  |  Cristillo, AD., et al. 1997. DNA Cell Biol. 16: 1449-58. PMID: 9428793
12. Mutation of a gene encoding a protein with extracellular matrix motifs in Usher syndrome type IIa.  |  Eudy, JD., et al. 1998. Science. 280: 1753-7. PMID: 9624053

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-G0S2 Antibody (D-1) has 3 citations in a variety of scientific publications.

Primary antibodies like Anti-G0S2 Antibody (D-1) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

G0S2 Antibody (D-1) Specifications

Alternate Product Name: G0S2

Product Clone Name: D-1

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 2-19

Epitope Target: G0S2

Epitope Species: human

Product Reactivity/Detection: G0S2

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 3 citations in various scientific publications

Available Conjugates/Forms for G0S2 Antibody (D-1): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin