FXR2 Antibody (G-2): sc-376963

FXR2 Antibody (G-2) is a mouse monoclonal IgG1 antibody that detects FXR2 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). FXR2 is a member of the fragile X family of proteins and plays a crucial role in the regulation of mRNA translation and stability, which is vital for proper neuronal function and development. FXR2 is predominantly located in the cytoplasm, where FXR2 associates with polyribosomes, facilitating the translation of specific mRNAs that are essential for synaptic plasticity and cognitive function. FXR2′s presence in the cytoplasm underscores its importance in the post-transcriptional regulation of gene expression, particularly in neurons, where precise control of protein synthesis is necessary for learning and memory processes. Additionally, FXR2 interacts with other fragile X-related proteins, such as FMRP and FXR1, forming heterodimeric complexes that are involved in the transport and localization of mRNAs within the cell. FXR2′s ability to modulate these interactions highlights its significance in the fragile X syndrome pathology, where disruptions in these protein networks can lead to cognitive impairments. Anti-FXR2 antibody (G-2) is an essential tool for researchers studying the molecular mechanisms underlying fragile X syndrome and related disorders.

The preferred FXR2 antibody is FXR2 Antibody (1G2): sc-32266.