FXR1 Antibody (D-4): sc-515365

FXR1 Antibody (D-4) is a mouse monoclonal IgG3 antibody that detects FXR1 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). FXR1, or fragile X mental retardation 1 protein, plays a crucial role in the regulation of mRNA translation and stability, which is vital for proper neuronal function and development. FXR1 is predominantly located in the cytoplasm, where FXR1 associates with polyribosomes, facilitating the translation of specific mRNAs that are essential for synaptic plasticity and cognitive processes. The presence of FXR1 in the cytoplasm underscores its importance in the local translation of proteins in response to synaptic activity, which is critical for learning and memory. Additionally, FXR1 interacts with other proteins related to fragile X syndrome, such as FMRP and FXR2, forming heterodimers that may influence the regulation of mRNA targets. The ability of FXR1 to shuttle between the nucleus and cytoplasm, aided by nuclear localization and export signals, further emphasizes FXR1′s role in the dynamic regulation of gene expression and mRNA transport, making FXR1 a significant focus for understanding the molecular mechanisms underlying fragile X syndrome and related disorders.

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FXR1 Antibody (D-4) References:

1. FXR1 is elevated in colorectal cancer and acts as an oncogene.  |  Jin, X., et al. 2016. Tumour Biol. 37: 2683-90. PMID: 26404134
2. Immunohistochemical Expression of FXR1 in Canine Normal Tissues and Melanomas.  |  Nordio, L., et al. 2018. J Histochem Cytochem. 66: 585-593. PMID: 29608406
3. The RNA-binding protein FXR1 modulates prostate cancer progression by regulating FBXO4.  |  Cao, H., et al. 2019. Funct Integr Genomics. 19: 487-496. PMID: 30746571
4. Muscle-Specific FXR1 Isoforms in Squamous Cell Cancer.  |  McClure, JJ. and Palanisamy, V. 2019. Trends Cancer. 5: 82-84. PMID: 30755307
5. FXR1 facilitates axitinib resistance in clear cell renal cell carcinoma via regulating KEAP1/Nrf2 signaling pathway.  |  Huang, H., et al. 2023. Anticancer Drugs. 34: 248-256. PMID: 36730618
6. Fragile X-Related Protein FXR1 Controls Human Adenovirus Capsid mRNA Metabolism.  |  Hajikhezri, Z., et al. 2023. J Virol. 97: e0153922. PMID: 36749074
7. FXR1 regulates vascular smooth muscle cell cytoskeleton, VSMC contractility, and blood pressure by multiple mechanisms.  |  St Paul, A., et al. 2023. Cell Rep. 42: 112381. PMID: 37043351
8. The multifaceted role of Fragile X-Related Protein 1 (FXR1) in cellular processes: an updated review on cancer and clinical applications.  |  Khan, FA., et al. 2024. Cell Death Dis. 15: 72. PMID: 38238286
9. FXR1 stabilizes SNORD63 to regulate blood-tumor barrier permeability through SNORD63 mediated 2'-O-methylation of POU6F1.  |  Liang, C., et al. 2024. Int J Biol Macromol. 265: 130642. PMID: 38460644
10. The Spatial-Temporal Alternative Splicing Profile Reveals the Functional Diversity of FXR1 Isoforms in Myogenesis.  |  Wang, W., et al. 2024. Adv Sci (Weinh). 11: e2405157. PMID: 39499773

The preferred FXR1 antibody is FXR1 Antibody (B-2): sc-374148.