FXR1 Antibody (C-4): sc-515398
- FXR1 Antibody (C-4) is a mouse monoclonal IgG3 κ provided at 200 µg/ml
- specific for an epitope mapping between amino acids 510-532 within an internal region of FXR1 of human origin
- recommended for detection of FXR1 of mouse, rat and human origin by WB, IP, IF and ELISA
- See FXR1 (B-2): sc-374148 for FXR1 antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- m-IgG3 BP-HRP is the preferred secondary detection reagent for FXR1 Antibody (C-4) for WB applications. This reagent is now offered in a bundle with FXR1 Antibody (C-4) (see ordering information below).
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FXR1 Antibody (C-4) is a mouse monoclonal IgG3 antibody that detects FXR1 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). FXR1, or fragile X mental retardation 1 protein, plays a crucial role in regulating mRNA translation and is essential for synaptic function and plasticity, which are vital for learning and memory processes. FXR1 is predominantly located in the cytoplasm, where FXR1 associates with polyribosomes, facilitating the transport and translation of specific mRNAs. Such localization allows for timely and spatially regulated expression of proteins necessary for neuronal development and function. Additionally, FXR1 interacts with other proteins related to fragile X syndrome, such as FMRP and FXR2, forming heterodimers important for messenger ribonucleoprotein complex assembly. Proper functioning of FXR1 is critical, as dysregulation can contribute to the pathophysiology of fragile X syndrome and other neurodevelopmental disorders.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
FXR1 Antibody (C-4) References:
- FXR1 Is an IL-19-Responsive RNA-Binding Protein that Destabilizes Pro-inflammatory Transcripts in Vascular Smooth Muscle Cells. | Herman, AB., et al. 2018. Cell Rep. 24: 1176-1189. PMID: 30067974
- FXR1 promotes the malignant biological behavior of glioma cells via stabilizing MIR17HG. | Cao, S., et al. 2019. J Exp Clin Cancer Res. 38: 37. PMID: 30691465
- RNA binding protein FXR1-miR301a-3p axis contributes to p21WAF1 degradation in oral cancer. | Majumder, M. and Palanisamy, V. 2020. PLoS Genet. 16: e1008580. PMID: 31940341
- FXR1 splicing is important for muscle development and biomolecular condensates in muscle cells. | Smith, JA., et al. 2020. J Cell Biol. 219: PMID: 32328638
- Fragile X-Related Protein 1 (FXR1) Promotes Trophoblast Migration at Early Pregnancy via Downregulation of GDF-15 Expression. | Hong, W., et al. 2022. Reprod Sci. 29: 110-121. PMID: 34291416
- FXR1 can bind with the CFIm25/CFIm68 complex and promote the progression of urothelial carcinoma of the bladder by stabilizing TRAF1 mRNA. | Deng, M., et al. 2022. Cell Death Dis. 13: 170. PMID: 35194031
- CEP63 upregulates YAP1 to promote colorectal cancer progression through stabilizing RNA binding protein FXR1. | Ling, H., et al. 2022. Oncogene. 41: 4433-4445. PMID: 35989368
- Comprehensive bioinformatics analysis of FXR1 across pan-cancer: Unraveling its diagnostic, prognostic, and immunological significance. | Xiao, K., et al. 2023. Medicine (Baltimore). 102: e36456. PMID: 38050239
- Targeting KIFC1 Promotes Senescence in Soft Tissue Sarcoma via FXR1-Dependent Regulation of MAD2L1 mRNA Stability. | Lu, XX., et al. 2024. Adv Sci (Weinh). 11: e2405611. PMID: 39387242
- FXR1 associates with and degrades PDZK1IP1 and ATOH8 mRNAs and promotes esophageal cancer progression. | Khan, FA., et al. 2024. Biol Direct. 19: 104. PMID: 39511680
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
FXR1 Antibody (C-4) | sc-515398 | 200 µg/ml | $322.00 | |||
FXR1 Antibody (C-4): m-IgG3 BP-HRP Bundle | sc-550535 | 200 µg Ab; 40 µg BP | $361.00 | |||
FXR1 (C-4) Neutralizing Peptide | sc-515398 P | 100 µg/0.5 ml | $69.00 |