FX Antibody (43.1): sc-100531

FX Antibody (43.1) is a mouse monoclonal IgG3 kappa light chain antibody that detects the FX protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). Anti-FX antibody (43.1) is available as the non-conjugated form. FX protein, also known as GDP-L-fucose synthetase or Tissue-specific transplantation antigen P35B, plays a crucial role in the biosynthesis of GDP-L-fucose, a key substrate for various fucosyltransferases involved in the modification of glycoproteins and glycolipids. This modification is essential for the proper expression of several glycoconjugates, including blood group ABH antigens and developmental adhesion molecules, which are vital for cell-cell interactions and immune responses. FX protein functions as a red cell NADP(H)-binding protein and is integral to leukocyte adhesion and trafficking processes, making FX protein important for immune system functionality. Notably, defects in the gene encoding FX protein can lead to leukocyte adhesion deficiency (LAD), a condition that impairs the immune response and increases susceptibility to infections.

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FX Antibody (43.1) References:

1. Decreased availability of GDP-L-fucose in a patient with LAD II with normal GDP-D-mannose dehydratase and FX protein activities.  |  Körner, C., et al. 1999. J Leukoc Biol. 66: 95-8. PMID: 10410995
2. Genetic variation in the quantitative levels of an NADP (H)-binding protein (FX) in human erythrocytes.  |  Lenzerini, L., et al. 1981. Blood. 57: 209-17. PMID: 7448421
3. Primary structure of human erythrocyte nicotinamide adenine dinucleotide phosphate (NADP[H])-binding protein FX: identification with the mouse tum- transplantation antigen P35B.  |  Camardella, L., et al. 1995. Blood. 85: 264-7. PMID: 7803801
4. Molecular cloning of human GDP-mannose 4,6-dehydratase and reconstitution of GDP-fucose biosynthesis in vitro.  |  Sullivan, FX., et al. 1998. J Biol Chem. 273: 8193-202. PMID: 9525924
5. Molecular cloning and expression of GDP-D-mannose-4,6-dehydratase, a key enzyme for fucose metabolism defective in Lec13 cells.  |  Ohyama, C., et al. 1998. J Biol Chem. 273: 14582-7. PMID: 9603974

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-FX Antibody (43.1) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-FX Antibody (43.1) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

FX Antibody (43.1) Specifications

Alternate Product Name: FX

Product Clone Name: 43.1

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₃ kappa light chain

Amino Acids: 222-322

Epitope Target: FX

Epitope Species: human

Product Reactivity/Detection: FX

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, ELISA

Vialing Information: Each vial contains 100 µg IgG₃ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for FX Antibody (43.1): N/A