FUT2 Antibody (9T-8): sc-100742

FUT2 Antibody (9T-8) is a mouse monoclonal IgG2a kappa light chain antibody that detects FUT2 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). FUT2 (9T-8) antibody is available as the non-conjugated form. FUT2 plays a crucial role in the synthesis of the H antigen, a fundamental component of the ABO blood group system. FUT2 is primarily located in secretory tissues, including the salivary glands and gastrointestinal tract, where FUT2 facilitates the addition of fucose to glycoproteins and glycolipids, thereby influencing blood group antigen expression and secretion. The presence or absence of the H antigen can significantly impact blood transfusion compatibility and susceptibility to certain infections, making FUT2 an important protein in both clinical and research settings. Additionally, the FUT2 locus exhibits extensive polymorphism, which is essential for understanding population genetics and the evolutionary dynamics of human blood groups. Anti-FUT2 antibody (9T-8) is particularly valuable for studies involving human tumor cell lines, as FUT2 is expressed on the surface of several such lines, including BEL-7404, SPC-A-1, and SGC-7901, providing insights into tumor biology and potential therapeutic targets.

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FUT2 Antibody (9T-8) References:

1. Molecular cloning, genomic mapping, and expression of two secretor blood group alpha (1,2)fucosyltransferase genes differentially regulated in mouse uterine epithelium and gastrointestinal tract.  |  Domino, SE., et al. 2001. J Biol Chem. 276: 23748-56. PMID: 11323419
2. FUT2 gene involved in expression of H blood group antigen on surface of human tumor cell lines BEL-7404, SGC-7901, and SPC-A-1.  |  Xing, L. and Guo, LH. 2000. Acta Pharmacol Sin. 21: 997-1001. PMID: 11501068
3. Organization of the bovine alpha 2-fucosyltransferase gene cluster suggests that the Sec1 gene might have been shaped through a nonautonomous L1-retrotransposition event within the same locus.  |  Saunier, K., et al. 2001. Mol Biol Evol. 18: 2083-91. PMID: 11606704
4. Polymorphism and distribution of the Secretor alpha(1,2)-fucosyltransferase gene in various Taiwanese populations.  |  Yu, LC., et al. 2001. Transfusion. 41: 1279-84. PMID: 11606829
5. Polymorphism of the human ABO-Secretor locus (FUT2) in four populations in Asia: indication of distinct Asian subpopulations.  |  Pang, H., et al. 2001. Ann Hum Genet. 65: 429-37. PMID: 11806852
6. Molecular analysis of mutations and polymorphisms of the Lewis secretor type alpha(1,2)-fucosyltransferase gene reveals that Taiwan aborigines are of Austronesian derivation.  |  Chang, JG., et al. 2002. J Hum Genet. 47: 60-5. PMID: 11916003
7. Molecular basis for H blood group deficiency in Bombay (Oh) and para-Bombay individuals.  |  Kelly, RJ., et al. 1994. Proc Natl Acad Sci U S A. 91: 5843-7. PMID: 7912436
8. Two missense mutations of H type alpha(1,2)fucosyltransferase gene (FUT1) responsible for para-Bombay phenotype.  |  Wang, B., et al. 1997. Vox Sang. 72: 31-5. PMID: 9031498
9. Missense mutation of FUT1 and deletion of FUT2 are responsible for Indian Bombay phenotype of ABO blood group system.  |  Koda, Y., et al. 1997. Biochem Biophys Res Commun. 238: 21-5. PMID: 9299444

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-FUT2 Antibody (9T-8) has 3 citations in a variety of scientific publications.

Primary antibodies like Anti-FUT2 Antibody (9T-8) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

FUT2 Antibody (9T-8) Specifications

Alternate Product Name: FUT2

Product Clone Name: 9T-8

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2a kappa light chain

Amino Acids: 51-151

Epitope Target: FUT2

Epitope Species: human

Product Reactivity/Detection: FUT2

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, ELISA

Vialing Information: Each vial contains 100 µg IgG_2a kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 3 citations in various scientific publications

Available Conjugates/Forms for FUT2 Antibody (9T-8): N/A