FUS-2 Antibody (AT2F4): sc-517402

FUS-2 Antibody (AT2F4) is a mouse monoclonal IgG1 kappa light chain antibody that detects the FUS-2 protein of human origin by western blotting (WB), immunofluorescence (IF), flow cytometry (FCM), and enzyme-linked immunosorbent assay (ELISA). Anti-FUS-2 antibody (AT2F4) is available as a non-conjugated format. FUS-2, consisting of 314 amino acids and encoded by the human gene NAT6, plays a crucial role in cellular processes as a member of the acetyltransferase family, which is vital for regulating various biological functions. FUS-2 is primarily located in the cytoplasm of cells, where FUS-2 is involved in the N-acetylation of specific peptides, particularly those with an N-terminal methionine followed by aspartate, glutamate, or asparagine. This post-translational modification influences protein stability, localization, and interactions, thereby impacting cellular signaling pathways and gene expression. FUS-2 has been implicated in tumor suppression, highlighting FUS-2′s potential role in cancer biology. This enzyme operates through a unique binary ping-pong mechanism, forming a covalent intermediate with acetyl-coenzyme A, which is essential for the transfer of the acetyl group to the substrate. This intricate process underscores FUS-2′s importance in maintaining cellular homeostasis and potential implications in disease states, making FUS-2 (AT2F4) monoclonal antibody a valuable tool for researchers studying these critical biological functions.

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FUS-2 Antibody (AT2F4) References:

1. Keyhole limpet hemocyanin type 2 (KLH2): detection and immunolocalization of a labile functional unit h.  |  Gebauer, W., et al. 1999. J Struct Biol. 128: 280-6. PMID: 10633067
2. The putative tumour suppressor Fus-2 is an N-acetyltransferase.  |  Zegerman, P., et al. 2000. Oncogene. 19: 161-3. PMID: 10644992
3. The 630-kb lung cancer homozygous deletion region on human chromosome 3p21.3: identification and evaluation of the resident candidate tumor suppressor genes. The International Lung Cancer Chromosome 3p21.3 Tumor Suppressor Gene Consortium.  |  Lerman, MI. and Minna, JD. 2000. Cancer Res. 60: 6116-33. PMID: 11085536
4. Composition and function of the eukaryotic N-terminal acetyltransferase subunits.  |  Polevoda, B. and Sherman, F. 2003. Biochem Biophys Res Commun. 308: 1-11. PMID: 12890471
5. Characterization of a new SNP c767A/T (Arg222Trp) in the candidate TSG FUS2 on human chromosome 3p21.3: prevalence in Asian populations and analysis of association with nasopharyngeal cancer.  |  Duh, FM., et al. 2004. Mol Cell Probes. 18: 39-44. PMID: 15036368
6. Structural and expression analysis of the porcine FUS2 gene.  |  Gatphayak, K., et al. 2004. Gene. 337: 105-11. PMID: 15276206
7. Modification of N-acetyltransferases and glutathione S-transferases by coffee components: possible relevance for cancer risk.  |  Huber, WW. and Parzefall, W. 2005. Methods Enzymol. 401: 307-41. PMID: 16399395

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-FUS-2 Antibody (AT2F4) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-FUS-2 Antibody (AT2F4) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

FUS-2 Antibody (AT2F4) Specifications

Alternate Product Name: FUS-2

Product Clone Name: AT2F4

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 1-308

Epitope Target: FUS-2

Epitope Species: human

Product Reactivity/Detection: FUS-2

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IF, FCM, ELISA

Vialing Information: Each vial contains 100 µg IgG₁ kappa light chain in 1.0 ml of PBS (pH 7.4) with 0.02% sodium azide and 10% glycerol

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for FUS-2 Antibody (AT2F4): N/A