Fucokinase Antibody (F-9): sc-377371
- Fucokinase Antibody (F-9) is a mouse monoclonal IgG1 κ Fucokinase antibody, cited in 1 publications, provided at 200 µg/ml
- specific for an epitope mapping between amino acids 433-465 within an internal region of Fucokinase of human origin
- Fucokinase Antibody (F-9) is recommended for detection of Fucokinase isoforms 1 and 2 of mouse, rat and human origin by WB, IP, IF and ELISA
- Anti-Fucokinase Antibody (F-9) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP and m-IgG1 BP-HRP are the preferred secondary detection reagents for Fucokinase Antibody (F-9) for WB applications. These reagents are now offered in bundles with Fucokinase Antibody (F-9) (see ordering information below).
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Fucokinase Antibody (F-9) is a mouse monoclonal IgG1 kappa light chain antibody that detects Fucokinase of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Fucokinase (F-9) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. Fucokinase, also known as L-fucose kinase or FUK, is a crucial enzyme in the salvage pathway of fucose reutilization, catalyzing the phosphorylation of L-fucose to produce β-L-fucose 1-phosphate. This process is vital for the synthesis of glycoproteins and glycolipids, which play significant roles in cell signaling, immune response, and cellular adhesion. Fucokinase consists of 1,084 amino acids and belongs to the GHMP kinase family, exhibiting two alternative splice variants. The gene encoding Fucokinase is located on human chromosome 16, a region associated with several genetic disorders, including giant axonal neuropathy and Rubinstein-Taybi syndrome. Fucokinase′s importance extends beyond enzymatic function, playing key roles in blood group antigen recognition, metastasis, and inflammation, all of which utilize fucose, a sugar essential for various cellular interactions and signaling pathways.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
Fucokinase Antibody (F-9) References:
- The gene encoding gigaxonin, a new member of the cytoskeletal BTB/kelch repeat family, is mutated in giant axonal neuropathy. | Bomont, P., et al. 2000. Nat Genet. 26: 370-4. PMID: 11062483
- Giant axonal neuropathy (GAN): case report and two novel mutations in the gigaxonin gene. | Kuhlenbäumer, G., et al. 2002. Neurology. 58: 1273-6. PMID: 11971098
- Identification of human L-fucose kinase amino acid sequence. | Hinderlich, S., et al. 2002. Biochem Biophys Res Commun. 294: 650-4. PMID: 12056818
- Genetics of inflammatory bowel disease: progress and prospects. | Mathew, CG. and Lewis, CM. 2004. Hum Mol Genet. 13 Spec No 1: R161-8. PMID: 14764625
- The Rubinstein-Taybi syndrome: occurrence in two sets of identical twins. | Baraitser, M. and Preece, MA. 1983. Clin Genet. 23: 318-20. PMID: 6682729
- Rubinstein-Taybi syndrome caused by submicroscopic deletions within 16p13.3. | Breuning, MH., et al. 1993. Am J Hum Genet. 52: 249-54. PMID: 8430691
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Fucokinase Antibody (F-9) | sc-377371 | 200 µg/ml | $316.00 | |||
Fucokinase Antibody (F-9): m-IgG Fc BP-HRP Bundle | sc-527600 | 200 µg Ab; 10 µg BP | $354.00 | |||
Fucokinase Antibody (F-9): m-IgG1 BP-HRP Bundle | sc-532973 | 200 µg Ab; 20 µg BP | $354.00 | |||
Fucokinase Antibody (F-9) AC | sc-377371 AC | 500 µg/ml, 25% agarose | $416.00 | |||
Fucokinase Antibody (F-9) HRP | sc-377371 HRP | 200 µg/ml | $316.00 | |||
Fucokinase Antibody (F-9) FITC | sc-377371 FITC | 200 µg/ml | $330.00 | |||
Fucokinase Antibody (F-9) PE | sc-377371 PE | 200 µg/ml | $343.00 | |||
Fucokinase Antibody (F-9) Alexa Fluor® 488 | sc-377371 AF488 | 200 µg/ml | $357.00 | |||
Fucokinase Antibody (F-9) Alexa Fluor® 546 | sc-377371 AF546 | 200 µg/ml | $357.00 | |||
Fucokinase Antibody (F-9) Alexa Fluor® 594 | sc-377371 AF594 | 200 µg/ml | $357.00 | |||
Fucokinase Antibody (F-9) Alexa Fluor® 647 | sc-377371 AF647 | 200 µg/ml | $357.00 | |||
Fucokinase Antibody (F-9) Alexa Fluor® 680 | sc-377371 AF680 | 200 µg/ml | $357.00 | |||
Fucokinase Antibody (F-9) Alexa Fluor® 790 | sc-377371 AF790 | 200 µg/ml | $357.00 | |||
Fucokinase (F-9) Neutralizing Peptide | sc-377371 P | 100 µg/0.5 ml | $68.00 |