FUCA1 Antibody (G-12): sc-365496
- FUCA1 Antibody (G-12) is a mouse monoclonal IgG1 λ FUCA1 antibody, cited in 2 publications, provided at 200 µg/ml
- raised against amino acids 151-237 mapping within an internal region of FUCA1 of human origin
- FUCA1 Antibody (G-12) is recommended for detection of FUCA1 of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA
- Anti-FUCA1 Antibody (G-12) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgGλ BP-HRP (mouse IgGλ binding protein-HRP) is the preferred secondary detection reagent for FUCA1 Antibody (G-12) for WB and IHC(P) applications. This reagent is now offered in a bundle with FUCA1 Antibody (G-12) (see ordering information below). For additional m-IgGλ BP conjugates see our complete list of Mouse IgG Binding Proteins.
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FUCA1 Antibody (G-12) is a mouse monoclonal IgG1 antibody that detects FUCA1 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). FUCA1 (G-12) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. FUCA1 protein, also known as fucosidase, alpha-L-1, tissue, is a 466 amino acid isozyme that plays a crucial role in the hydrolysis of fucose-containing glycoproteins and glycolipids, primarily functioning as a homotetramer. FUCA1 enzymatic activity is vital for maintaining cellular homeostasis and proper glycoprotein metabolism, as defects in FUCA1 gene can lead to fucosidosis, a severe autosomal recessive lysosomal storage disorder characterized by the accumulation of fucose-containing compounds. Clinical manifestations of fucosidosis include neurologic deterioration, growth retardation, visceromegaly, and seizures, with early onset presenting additional symptoms such as coarse facial features and developmental delays. Understanding FUCA1 function is essential for elucidating biochemical pathways involved in glycoprotein degradation and implications of FUCA1 dysfunction in disease states.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
FUCA1 Antibody (G-12) References:
- Purification and characterization of human seminal plasma alpha-L-fucosidase. | Khunsook, S., et al. 2002. Mol Hum Reprod. 8: 221-7. PMID: 11870229
- A novel FUCA1 mutation causing fucosidosis in a Chinese boy. | Ip, P., et al. 2002. J Inherit Metab Dis. 25: 415-6. PMID: 12408193
- An alpha-L-fucosidase potentially involved in fertilization is present on Drosophila spermatozoa surface. | Intra, J., et al. 2006. Mol Reprod Dev. 73: 1149-58. PMID: 16736526
- Purification and characterization of alpha-L-fucosidase from human primary hepatocarcinoma tissue. | Li, C., et al. 2006. World J Gastroenterol. 12: 3770-5. PMID: 16773698
- Crypticity and functional distribution of the membrane associated alpha-L-fucosidase of human sperm. | Venditti, JJ., et al. 2007. Mol Reprod Dev. 74: 758-66. PMID: 17133604
- Mutation identification and characterization of a Taiwanese patient with fucosidosis. | Lin, SP., et al. 2007. J Hum Genet. 52: 553-556. PMID: 17427030
- Genetically polymorphic alpha-L-fucosidase (FUCA1) isozymes detected in blood plasma. | Takeshita, H., et al. 1994. Hum Genet. 94: 224-30. PMID: 8076935
- Six additional mutations in fucosidosis: three nonsense mutations and three frameshift mutations. | Seo, HC., et al. 1993. Hum Mol Genet. 2: 1205-8. PMID: 8401503
- Fucosidosis: genetic and biochemical analysis of eight cases. | Cragg, H., et al. 1997. J Med Genet. 34: 105-10. PMID: 9039984
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
FUCA1 Antibody (G-12) | sc-365496 | 200 µg/ml | $316.00 | |||
FUCA1 Antibody (G-12): m-IgGλ BP-HRP Bundle | sc-522256 | 200 µg Ab, 40 µg BP | $354.00 | |||
FUCA1 Antibody (G-12) AC | sc-365496 AC | 500 µg/ml, 25% agarose | $416.00 | |||
FUCA1 Antibody (G-12) HRP | sc-365496 HRP | 200 µg/ml | $316.00 | |||
FUCA1 Antibody (G-12) FITC | sc-365496 FITC | 200 µg/ml | $330.00 | |||
FUCA1 Antibody (G-12) PE | sc-365496 PE | 200 µg/ml | $343.00 | |||
FUCA1 Antibody (G-12) Alexa Fluor® 488 | sc-365496 AF488 | 200 µg/ml | $357.00 | |||
FUCA1 Antibody (G-12) Alexa Fluor® 546 | sc-365496 AF546 | 200 µg/ml | $357.00 | |||
FUCA1 Antibody (G-12) Alexa Fluor® 594 | sc-365496 AF594 | 200 µg/ml | $357.00 | |||
FUCA1 Antibody (G-12) Alexa Fluor® 647 | sc-365496 AF647 | 200 µg/ml | $357.00 | |||
FUCA1 Antibody (G-12) Alexa Fluor® 680 | sc-365496 AF680 | 200 µg/ml | $357.00 | |||
FUCA1 Antibody (G-12) Alexa Fluor® 790 | sc-365496 AF790 | 200 µg/ml | $357.00 |