FTS Antibody (KK-L5): sc-134343

FTS Antibody (KK-L5) is a mouse monoclonal IgG1 kappa light chain antibody that detects FTS protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). Anti-FTS antibody (KK-L5) is available as the non-conjugated format. Fused toes protein homolog (FTS), also known as AKT-interacting protein (AKTIP) and Ft1, is a 292 amino acid protein primarily localized in the cytoplasm and cell membrane, crucial for cellular signaling pathways. FTS localization enables direct interaction with AKT1, a key regulator of various cellular processes including cell growth, protein synthesis, and antiapoptotic signaling. Through cytoplasmic and membrane positioning, FTS monoclonal antibody (KK-L5) can effectively modulate AKT1 activity, enhancing phosphorylation and activation. This interaction drives the AKT1/GSK-3β/NFATc1 signaling cascade, leading to increased production of proapoptotic hormone Fas ligand, promoting apoptosis in response to cellular stress. FTS (KK-L5) antibody influences apoptosis through AKT1 interaction, highlighting FTS significance in maintaining cellular homeostasis and responding to external stimuli.

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FTS Antibody (KK-L5) References:

1. Mechanism of phosphorylation of protein kinase B/Akt by a constitutively active 3-phosphoinositide-dependent protein kinase-1.  |  Wick, MJ., et al. 2000. J Biol Chem. 275: 40400-6. PMID: 11006271
2. Conditional knock-out of integrin-linked kinase demonstrates an essential role in protein kinase B/Akt activation.  |  Troussard, AA., et al. 2003. J Biol Chem. 278: 22374-8. PMID: 12686550
3. Regulation of apoptosis by the Ft1 protein, a new modulator of protein kinase B/Akt.  |  Remy, I. and Michnick, SW. 2004. Mol Cell Biol. 24: 1493-504. PMID: 14749367
4. A novel protein kinase B (PKB)/AKT-binding protein enhances PKB kinase activity and regulates DNA synthesis.  |  Anai, M., et al. 2005. J Biol Chem. 280: 18525-35. PMID: 15753085
5. Ft1, a novel gene related to ubiquitin-conjugating enzymes, is deleted in the Fused toes mouse mutation.  |  Lesche, R., et al. 1997. Mamm Genome. 8: 879-83. PMID: 9383278
6. Close linkage of p130 and Ft1 is conserved among mammals.  |  Lesche, R. and Rüther, U. 1998. Mamm Genome. 9: 253-5. PMID: 9501314

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-FTS Antibody (KK-L5) has 4 citations in a variety of scientific publications.

Primary antibodies like Anti-FTS Antibody (KK-L5) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

FTS Antibody (KK-L5) Specifications

Alternate Product Name: FTS

Product Clone Name: KK-L5

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 1-293

Epitope Target: FTS

Epitope Species: human

Product Reactivity/Detection: FTS

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, ELISA

Vialing Information: Each vial contains 100 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 4 citations in various scientific publications

Available Conjugates/Forms for FTS Antibody (KK-L5): N/A