FRRS1L Antibody (H-8): sc-398692
- FRRS1L Antibody (H-8) is a mouse monoclonal IgG2b κ FRRS1L antibody, cited in 2 publications, provided at 200 µg/ml
- specific for an epitope mapping between amino acids 229-264 within an internal region of FRRS1L of human origin
- FRRS1L Antibody (H-8) is recommended for detection of FRRS1L of mouse, rat and human origin by WB, IP, IF and ELISA
- Anti-FRRS1L Antibody (H-8) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG2b BP-HRP is the preferred secondary detection reagent for FRRS1L Antibody (H-8) for WB applications. This reagent is now offered in a bundle with FRRS1L Antibody (H-8) (see ordering information below).
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FRRS1L Antibody (H-8) is a mouse monoclonal IgG2b kappa light chain antibody that detects FRRS1L protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). FRRS1L (H-8) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. FRRS1L protein, also known as ferric-chelate reductase 1-like, brain protein CG-6, or C9orf4, is a 344 amino acid single-pass membrane protein primarily expressed in the adult and fetal brain, with weaker expression in the spinal cord, adult ovary, and medulla. FRRS1L protein plays a crucial role in the assembly and function of the AMPA receptor complex, which is essential for mediating fast synaptic transmission in the central nervous system. FRRS1L protein contains one DOMON domain and is encoded by a gene located on human chromosome 9q31.3. FRRS1L interaction with auxiliary subunits is vital for regulating the gating properties and surface trafficking of the AMPA receptor complex, thereby influencing their biogenesis and protein processing. FRRS1L ability to modulate these processes highlights its importance in synaptic plasticity and overall neuronal function, making FRRS1L protein a significant target for research in neurobiology and related fields.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
FRRS1L Antibody (H-8) References:
- Ca(2+)-permeable AMPA receptors induce phosphorylation of cAMP response element-binding protein through a phosphatidylinositol 3-kinase-dependent stimulation of the mitogen-activated protein kinase signaling cascade in neurons. | Perkinton, MS., et al. 1999. J Neurosci. 19: 5861-74. PMID: 10407026
- Cloning, mapping, and expression of a novel brain-specific transcript in the familial dysautonomia candidate region on chromosome 9q31. | Chadwick, BP., et al. 2000. Mamm Genome. 11: 81-3. PMID: 10603000
- Regulation of AMPA receptor endocytosis by a signaling mechanism shared with LTD. | Beattie, EC., et al. 2000. Nat Neurosci. 3: 1291-300. PMID: 11100150
- Regulation of AMPA receptors during synaptic plasticity. | Song, I. and Huganir, RL. 2002. Trends Neurosci. 25: 578-88. PMID: 12392933
- Kainate-induced excitotoxicity is dependent upon extracellular potassium concentrations that regulate the activity of AMPA/KA type glutamate receptors. | Ha, BK., et al. 2002. J Neurochem. 83: 934-45. PMID: 12421366
- Glutamate receptor ion channels. | Mayer, ML. 2005. Curr Opin Neurobiol. 15: 282-8. PMID: 15919192
- Activators of protein kinase C induce myotonia by lowering chloride conductance in muscle. | Brinkmeier, H. and Jockusch, H. 1987. Biochem Biophys Res Commun. 148: 1383-9. PMID: 2446609
- Coexpressed auxiliary subunits exhibit distinct modulatory profiles on AMPA receptor function. | Khodosevich, K., et al. 2014. Neuron. 83: 601-15. PMID: 25066086
- The binding of [3H]AMPA, a structural analogue of glutamic acid, to rat brain membranes. | Honoré, T., et al. 1982. J Neurochem. 38: 173-8. PMID: 6125564
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
FRRS1L Antibody (H-8) | sc-398692 | 200 µg/ml | $316.00 | |||
FRRS1L Antibody (H-8): m-IgG2b BP-HRP Bundle | sc-548788 | 200 µg Ab; 10 µg BP | $354.00 | |||
FRRS1L Antibody (H-8) AC | sc-398692 AC | 500 µg/ml, 25% agarose | $416.00 | |||
FRRS1L Antibody (H-8) HRP | sc-398692 HRP | 200 µg/ml | $316.00 | |||
FRRS1L Antibody (H-8) FITC | sc-398692 FITC | 200 µg/ml | $330.00 | |||
FRRS1L Antibody (H-8) PE | sc-398692 PE | 200 µg/ml | $343.00 | |||
FRRS1L Antibody (H-8) Alexa Fluor® 488 | sc-398692 AF488 | 200 µg/ml | $357.00 | |||
FRRS1L Antibody (H-8) Alexa Fluor® 546 | sc-398692 AF546 | 200 µg/ml | $357.00 | |||
FRRS1L Antibody (H-8) Alexa Fluor® 594 | sc-398692 AF594 | 200 µg/ml | $357.00 | |||
FRRS1L Antibody (H-8) Alexa Fluor® 647 | sc-398692 AF647 | 200 µg/ml | $357.00 | |||
FRRS1L Antibody (H-8) Alexa Fluor® 680 | sc-398692 AF680 | 200 µg/ml | $357.00 | |||
FRRS1L Antibody (H-8) Alexa Fluor® 790 | sc-398692 AF790 | 200 µg/ml | $357.00 | |||
FRRS1L (H-8) Neutralizing Peptide | sc-398692 P | 100 µg/0.5 ml | $68.00 |