frizzled-3 Antibody (C-1): sc-376105
- frizzled-3 Antibody (C-1) is a mouse monoclonal IgG2a κ frizzled-3 antibody, cited in 4 publications, provided at 200 µg/ml
- raised against amino acids 501-666 mapping at the C-terminus of frizzled-3 of human origin
- frizzled-3 Antibody (C-1) is recommended for detection of frizzled-3 of mouse, rat and human origin by WB, IP, IF and ELISA; also reactive with additional species, including and equine and bovine
- Anti-frizzled-3 Antibody (C-1) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG2a BP-HRP is the preferred secondary detection reagent for frizzled-3 Antibody (C-1) for WB applications. This reagent is now offered in a bundle with frizzled-3 Antibody (C-1) (see ordering information below).
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frizzled-3 Antibody (C-1) is a mouse monoclonal IgG2a kappa light chain antibody that detects frizzled-3 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). anti-frizzled-3 antibody (C-1) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. frizzled-3, a member of the frizzled family, plays a crucial role in the Wnt signaling pathway, which is essential for various developmental processes, including tissue polarity and cell fate determination. Located primarily in the cell membrane, frizzled-3 contains seven transmembrane domains and a cysteine-rich extracellular domain, which are vital for functioning as a receptor for Wnt ligands. This receptor′s ability to interact with G proteins is significant, as frizzled-3 influences the intracellular levels of β-catenin, a key player in regulating gene expression and maintaining cellular homeostasis. frizzled-3 is notably expressed in the central nervous system and has been implicated in conditions such as schizophrenia, highlighting frizzled-3′s importance in neural development and function. Additionally, alternative splicing of the frizzled-3 gene results in two distinct isoforms, further diversifying functional roles in various biological contexts.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
frizzled-3 Antibody (C-1) References:
- Molecular cloning and genomic structure of human frizzled-3 at chromosome 8p21. | Kirikoshi, H., et al. 2000. Biochem Biophys Res Commun. 271: 8-14. PMID: 10777673
- Identification, gene structure, and expression of human frizzled-3 (FZD3). | Sala, CF., et al. 2000. Biochem Biophys Res Commun. 273: 27-34. PMID: 10873558
- Kermit, a frizzled interacting protein, regulates frizzled 3 signaling in neural crest development. | Tan, C., et al. 2001. Development. 128: 3665-74. PMID: 11585793
- Frizzled-3 is required for the development of major fiber tracts in the rostral CNS. | Wang, Y., et al. 2002. J Neurosci. 22: 8563-73. PMID: 12351730
- The human frizzled-3 (FZD3) gene on chromosome 8p21, a receptor gene for Wnt ligands, is associated with the susceptibility to schizophrenia. | Katsu, T., et al. 2003. Neurosci Lett. 353: 53-6. PMID: 14642436
- Investigation of genetic association between human Frizzled homolog 3 gene (FZD3) and schizophrenia: results in a Korean population and evidence from meta-analysis. | Jeong, SH., et al. 2006. Psychiatry Res. 143: 1-11. PMID: 16707163
- Common dysregulation of Wnt/Frizzled receptor elements in human hepatocellular carcinoma. | Bengochea, A., et al. 2008. Br J Cancer. 99: 143-50. PMID: 18577996
- The Frizzled 3 gene is associated with methamphetamine psychosis in the Japanese population. | Kishimoto, M., et al. 2008. Behav Brain Funct. 4: 37. PMID: 18702828
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
frizzled-3 Antibody (C-1) | sc-376105 | 200 µg/ml | $322.00 | |||
frizzled-3 Antibody (C-1): m-IgG2a BP-HRP Bundle | sc-545946 | 200 µg Ab; 10 µg BP | $361.00 | |||
frizzled-3 Antibody (C-1) AC | sc-376105 AC | 500 µg/ml, 25% agarose | $424.00 | |||
frizzled-3 Antibody (C-1) HRP | sc-376105 HRP | 200 µg/ml | $322.00 | |||
frizzled-3 Antibody (C-1) FITC | sc-376105 FITC | 200 µg/ml | $336.00 | |||
frizzled-3 Antibody (C-1) PE | sc-376105 PE | 200 µg/ml | $349.00 | |||
frizzled-3 Antibody (C-1) Alexa Fluor® 488 | sc-376105 AF488 | 200 µg/ml | $364.00 | |||
frizzled-3 Antibody (C-1) Alexa Fluor® 546 | sc-376105 AF546 | 200 µg/ml | $364.00 | |||
frizzled-3 Antibody (C-1) Alexa Fluor® 594 | sc-376105 AF594 | 200 µg/ml | $364.00 | |||
frizzled-3 Antibody (C-1) Alexa Fluor® 647 | sc-376105 AF647 | 200 µg/ml | $364.00 | |||
frizzled-3 Antibody (C-1) Alexa Fluor® 680 | sc-376105 AF680 | 200 µg/ml | $364.00 | |||
frizzled-3 Antibody (C-1) Alexa Fluor® 790 | sc-376105 AF790 | 200 µg/ml | $364.00 |