frizzled-1 Antibody (E-7): sc-398082

frizzled-1 Antibody (E-7) is a mouse monoclonal IgM kappa antibody that detects frizzled-1 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). anti-frizzled-1 antibody (E-7) is available as a non-conjugated format. frizzled-1 protein plays a crucial role in the Wnt signaling pathway, which is essential for various developmental processes, including cell proliferation, differentiation, and tissue patterning. frizzled-1 acts as a receptor for Wnt ligands, initiating signaling cascades that influence gene expression and cellular behavior. frizzled-1 expression appears in key tissues such as heart, placenta, lung, kidney, pancreas, prostate, and ovary, as well as in fetal lung and kidney, highlighting its role in both embryonic and adult physiology. frizzled proteins, including frizzled-1, are characterized by seven transmembrane domains and a cysteine-rich extracellular domain, which are critical for their function as G protein-coupled receptors. Understanding frizzled-1 function is vital for elucidating its involvement in developmental disorders and potential therapeutic targets in diseases related to aberrant Wnt signaling.

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frizzled-1 Antibody (E-7) References:

1. Gene profiling of Frizzled-1 and Frizzled-2 signaling: expression of G-protein-coupled receptor chimeras in mouse F9 teratocarcinoma embryonal cells.  |  Li, H., et al. 2004. Mol Pharmacol. 65: 45-55. PMID: 14722236
2. Inhibition of Wnt/β-catenin signaling by a soluble collagen-derived frizzled domain interacting with Wnt3a and the receptors frizzled 1 and 8.  |  Hendaoui, I., et al. 2012. PLoS One. 7: e30601. PMID: 22303445
3. Interference of Frizzled 1 (FZD1) reverses multidrug resistance in breast cancer cells through the Wnt/β-catenin pathway.  |  Zhang, H., et al. 2012. Cancer Lett. 323: 106-113. PMID: 22484497
4. Frizzled-1 receptor regulates adult hippocampal neurogenesis.  |  Mardones, MD., et al. 2016. Mol Brain. 9: 29. PMID: 26980182
5. Frizzled 1 and Wnt1 as new potential therapeutic targets in the traumatically injured spinal cord.  |  González, P., et al. 2020. Cell Mol Life Sci. 77: 4631-4662. PMID: 31900623
6. A large family of putative transmembrane receptors homologous to the product of the Drosophila tissue polarity gene frizzled.  |  Wang, Y., et al. 1996. J Biol Chem. 271: 4468-76. PMID: 8626800
7. A frizzled homolog functions in a vertebrate Wnt signaling pathway.  |  Yang-Snyder, J., et al. 1996. Curr Biol. 6: 1302-6. PMID: 8939578
8. A family of secreted proteins contains homology to the cysteine-rich ligand-binding domain of frizzled receptors.  |  Rattner, A., et al. 1997. Proc Natl Acad Sci U S A. 94: 2859-63. PMID: 9096311
9. Purification and molecular cloning of a secreted, Frizzled-related antagonist of Wnt action.  |  Finch, PW., et al. 1997. Proc Natl Acad Sci U S A. 94: 6770-5. PMID: 9192640
10. SARPs: a family of secreted apoptosis-related proteins.  |  Melkonyan, HS., et al. 1997. Proc Natl Acad Sci U S A. 94: 13636-41. PMID: 9391078
11. A novel frizzled gene identified in human esophageal carcinoma mediates APC/beta-catenin signals.  |  Tanaka, S., et al. 1998. Proc Natl Acad Sci U S A. 95: 10164-9. PMID: 9707618
12. Molecular cloning, differential expression, and chromosomal localization of human frizzled-1, frizzled-2, and frizzled-7.  |  Sagara, N., et al. 1998. Biochem Biophys Res Commun. 252: 117-22. PMID: 9813155

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-frizzled-1 Antibody (E-7) has 9 citations in a variety of scientific publications.

Primary antibodies like Anti-frizzled-1 Antibody (E-7) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

frizzled-1 Antibody (E-7) Specifications

Alternate Product Name: frizzled-1

Product Clone Name: E-7

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgM kappa light chain

Amino Acids: 308-333

Epitope Target: frizzled-1

Epitope Species: human

Product Reactivity/Detection: precursor and mature frizzled-1, frizzled-2 and frizzled-7

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: equine, canine, bovine and avian

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgM kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 9 citations in various scientific publications

Available Conjugates/Forms for frizzled-1 Antibody (E-7): P: Blocking Peptide

The preferred frizzled antibody is frizzled Antibody (1C11): sc-13559.