FRG1 Antibody (L-07): sc-101050

FRG1 Antibody (L-07) is a mouse monoclonal IgG2a antibody that detects FRG1 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). FRG1 is a 258 amino acid nuclear protein encoded by the human gene FRG1, and plays a crucial role in the processing of pre-messenger RNA, particularly in pre-rRNA processing and the assembly of ribosomal RNA into ribosomal subunits. This function is vital for protein synthesis, as ribosomes are essential for translating mRNA into proteins, which are necessary for various cellular functions. Notably, FRG1 is implicated in facioscapulohumeral muscular dystrophy (FSHD), a genetic disorder characterized by muscle degeneration and retinal vascular abnormalities, which arise from increased expression of genes near the deletion in the D4Z4 repeat region on chromosome 4q35. FRG1 is expressed in both adult and fetal muscle, lymphocytes, and placenta, and can be localized to nuclear Cajal bodies or speckles, highlighting its importance in cellular processes. Anti-FRG1 antibody (L-07) is an invaluable tool for researchers studying the molecular mechanisms underlying FSHD and other related conditions, providing insights into FRG1′s function and role in muscle health and disease.

The preferred FRG1 antibody is FRG1 Antibody (C-5): sc-377040.