FOXN4 Antibody (H-2): sc-390456

FOXN4 Antibody (H-2) is a mouse monoclonal IgM antibody that detects FOXN4 of mouse origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-FOXN4 antibody (H-2) is available as the non-conjugated form. The human gene FOXN4 encodes a 476 amino acid nuclear protein that plays a crucial role in retina development by regulating retinal progenitor cell differentiation. Specifically, FOXN4 is essential for amacrine and horizontal cell formation, activating the expression of key retinogenic factors such as MATH-3, Neuro D, and PROX1. This regulatory function ensures proper diversification of neuronal subtypes, critical for forming a functional visual system. Additionally, during spinal neurogenesis, FOXN4 is coexpressed with bHLH factor ASH1 in a subset of progenitors, influencing the balance between distinct interneuron subtypes. FOXN4′s ability to modulate ASH1 and other factors underscores its importance in neuronal development and potential implications in neurodevelopmental disorders.

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FOXN4 Antibody (H-2) References:

1. A zebrafish orthologue (whnb) of the mouse nude gene is expressed in the epithelial compartment of the embryonic thymic rudiment.  |  Schorpp, M., et al. 2002. Mech Dev. 118: 179-85. PMID: 12351184
2. Out-foxing fate; molecular switches create neuronal diversity in the retina.  |  Kay, JN. and Baier, H. 2004. Neuron. 43: 759-60. PMID: 15363386
3. Foxn4 controls the genesis of amacrine and horizontal cells by retinal progenitors.  |  Li, S., et al. 2004. Neuron. 43: 795-807. PMID: 15363391
4. Expression of the winged helix/forkhead gene, foxn4, during zebrafish development.  |  Danilova, N., et al. 2004. Brain Res Dev Brain Res. 153: 115-9. PMID: 15464224
5. Human FOX gene family (Review).  |  Katoh, M. and Katoh, M. 2004. Int J Oncol. 25: 1495-500. PMID: 15492844
6. Characterization of human FOXN4 gene in silico.  |  Katoh, M. and Katoh, M. 2004. Int J Mol Med. 14: 949-53. PMID: 15492871
7. Foxn4 acts synergistically with Mash1 to specify subtype identity of V2 interneurons in the spinal cord.  |  Li, S., et al. 2005. Proc Natl Acad Sci U S A. 102: 10688-93. PMID: 16020526

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-FOXN4 Antibody (H-2) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-FOXN4 Antibody (H-2) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

FOXN4 Antibody (H-2) Specifications

Alternate Product Name: FOXN4

Product Clone Name: H-2

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgM kappa light chain

Amino Acids: 40-198

Epitope Target: FOXN4

Epitope Species: mouse

Product Reactivity/Detection: FOXN4

Species Reactivity/Detection: mouse

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgM kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for FOXN4 Antibody (H-2): N/A

The preferred FOXN4 antibody is FOXN4 Antibody (G-1): sc-377166.